Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus

被引：23

作者：

Acosta, Helena ^{[1
]}

Lopez, Silvia L. ^{[1
]}

Revinski, Diego R. ^{[1
]}

Carrasco, Andres E. ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencias, Lab Embriol Mol, RA-1121 Buenos Aires, DF, Argentina

来源：

DEVELOPMENT | 2011年 / 138卷 / 12期

关键词：

Notch; beta-catenin; BCNE; Dorsal-anterior development; Brain; Xenopus; AXIS SPECIFICATION; NEURAL INDUCTION; WNT/BETA-CATENIN; SIGNALING PATHWAYS; CORTICAL ROTATION; DORSOVENTRAL AXIS; SPEMANN ORGANIZER; RETINOIC ACID; HOMEOBOX GENE; CELL FATE;

D O I：

10.1242/dev.061143

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of beta-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain.

引用

页码：2567 / 2579

页数：13

共 72 条

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