Tissue-specific Cushing's syndrome uncovers a new target in treating the metabolic syndrome -: 11β-hydroxysteroid dehydrogenase type 1

被引：14
作者：
Stewart, PM [1 ]
机构：
[1] Univ Birmingham, Sch Med, Inst Biomed Res, Div Med Sci, Birmingham B15 2TT, W Midlands, England
来源：
CLINICAL MEDICINE | 2005年 / 5卷 / 02期
关键词：
11 beta-hydroxysteroid dehydrogenase; cortisol; Cushing's syndrome; diabetes; glucocorticoids; metabolic syndrome; metabolism; obesity;
D O I：
10.7861/clinmedicine.5-2-142
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：142 / 146
页数：5
相关论文
共 36 条
[1]   Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains [J].
Alberts, P ;
Nilsson, C ;
Selén, G ;
Engblom, LOM ;
Edling, NHM ;
Norling, S ;
Klingström, G ;
Larsson, C ;
Forsgren, M ;
Ashkzari, M ;
Nilsson, CE ;
Fiedler, M ;
Bergqvist, E ;
Öhman, B ;
Björkstrand, E ;
Abrahmsén, LB .
ENDOCRINOLOGY, 2003, 144 (11) :4755-4762
[2]   Selective inhibition of 11β-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice [J].
Alberts, P ;
Engblom, L ;
Edling, N ;
Forsgren, M ;
Klingström, G ;
Larsson, C ;
Rönquist-Nii, Y ;
Öhman, B ;
Abrahmsén, L .
DIABETOLOGIA, 2002, 45 (11) :1528-1532
[3]   Effects of the 11β-hydroxysteroid dehydrogrenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes [J].
Andrews, RC ;
Rooyackers, O ;
Walker, BR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (01) :285-291
[4]   CLONING OF HUMAN MINERALOCORTICOID RECEPTOR COMPLEMENTARY-DNA - STRUCTURAL AND FUNCTIONAL KINSHIP WITH THE GLUCOCORTICOID RECEPTOR [J].
ARRIZA, JL ;
WEINBERGER, C ;
CERELLI, G ;
GLASER, TM ;
HANDELIN, BL ;
HOUSMAN, DE ;
EVANS, RM .
SCIENCE, 1987, 237 (4812) :268-275
[5]   Peroxisome proliferator-activated receptor-γ ligands inhibit adipocyte 11β-hydroxysteroid dehydrogenase type 1 expression and activity [J].
Berger, J ;
Tanen, M ;
Elbrecht, A ;
Hermanowski-Vosatka, A ;
Moller, DE ;
Wright, SD ;
Thieringer, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (16) :12629-12635
[6]   Differentiation of adipose stromal cells:: The roles of glucocorticoids and 11β-hydroxysteroid dehydrogenase [J].
Bujalska, IJ ;
Kumar, S ;
Hewison, M ;
Stewart, PM .
ENDOCRINOLOGY, 1999, 140 (07) :3188-3196
[7]   Does central obesity reflect ''Cushing's disease of the omentum''? [J].
Bujalska, IJ ;
Kumar, S ;
Stewart, PM .
LANCET, 1997, 349 (9060) :1210-1213
[8]  
Cushing H, 1932, B JOHNS HOPKINS HOSP, V50, P137
[9]   ADIPOSE-TISSUE DISTRIBUTION AND PLASMA-LIPOPROTEIN LEVELS IN OBESE WOMEN - IMPORTANCE OF INTRA-ABDOMINAL FAT [J].
DESPRES, JP ;
MOORJANI, S ;
FERLAND, M ;
TREMBLAY, A ;
LUPIEN, PJ ;
NADEAU, A ;
PINAULT, S ;
THERIAULT, G ;
BOUCHARD, C .
ARTERIOSCLEROSIS, 1989, 9 (02) :203-210
[10]   LOCALIZATION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR [J].
EDWARDS, CRW ;
BURT, D ;
MCINTYRE, MA ;
DEKLOET, ER ;
STEWART, PM ;
BRETT, L ;
SUTANTO, WS ;
MONDER, C .
LANCET, 1988, 2 (8618) :986-989
1234