FANCD2 and DNA Damage

被引：55
作者：
Nepal, Manoj [1 ,2 ]
Che, Raymond [1 ,2 ]
Ma, Chi [1 ]
Zhang, Jun [3 ]
Fei, Peiwen [1 ,2 ]
机构：
[1] Univ Hawaii, Ctr Canc, Canc Biol Program, Honolulu, HI 96813 USA
[2] Univ Hawaii, Grad Program Mol Biosci & Bioengn, Honolulu, HI 96813 USA
[3] Mayo Clin Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 08期
关键词：
Fanconi anemia; FANCD2; DNA damage repair; checkpoint; cancer and aging; CROSS-LINK REPAIR; FANCONI-ANEMIA PATHWAY; MONOUBIQUITINATED PCNA; TRANSLESION SYNTHESIS; BIALLELIC MUTATIONS; RESPONSE NETWORK; UBIQUITIN LIGASE; POLYMERASE-ETA; BRCA PROTEINS; CANCER-CELLS;
D O I：
10.3390/ijms18081804
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal point of FA signaling and plays crucial roles in multiple aspects of cellular life, especially in the cellular responses to DNA damage. Here, we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.
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页数：9
相关论文
共 76 条
[1]   Monoubiquitylation in the Fanconi anemia DNA damage response pathway [J].
Alpi, A. F. ;
Patel, K. J. .
DNA REPAIR, 2009, 8 (04) :430-435
[2]   Mechanistic Insight into Site-Restricted Monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI [J].
Alpi, Arno F. ;
Pace, Paul E. ;
Babu, M. Madan ;
Patel, Ketan J. .
MOLECULAR CELL, 2008, 32 (06) :767-777
[3]   Cancer in Fanconi anemia, 1927-2001 [J].
Alter, BP .
CANCER, 2003, 97 (02) :425-440
[4]   A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51 [J].
Ameziane, Najim ;
May, Patrick ;
Haitjema, Anneke ;
van de Vrugt, Henri J. ;
van Rossum-Fikkert, Sari E. ;
Ristic, Dejan ;
Williams, Gareth J. ;
Balk, Jesper ;
Rockx, Davy ;
Li, Hong ;
Rooimans, Martin A. ;
Oostra, Anneke B. ;
Velleuer, Eunike ;
Dietrich, Ralf ;
Bleijerveld, Onno B. ;
Altelaar, A. F. Maarten ;
Meijers-Heijboer, Hanne ;
Joenje, Hans ;
Glusman, Gustavo ;
Roach, Jared ;
Hood, Leroy ;
Galas, David ;
Wyman, Claire ;
Balling, Rudi ;
den Dunnen, Johan ;
de Winter, Johan P. ;
Kanaar, Roland ;
Gelinas, Richard ;
Dorsman, Josephine C. .
NATURE COMMUNICATIONS, 2015, 6
[5]   Genetic basis of Fanconi anemia [J].
Bagby, GC .
CURRENT OPINION IN HEMATOLOGY, 2003, 10 (01) :68-76
[6]   Checking on DNA damage in S phase [J].
Bartek, J ;
Lukas, C ;
Lukas, J .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (10) :792-804
[7]   Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].
Bienko, M ;
Green, CM ;
Crosetto, N ;
Rudolf, F ;
Zapart, G ;
Coull, B ;
Kannouche, P ;
Wider, G ;
Peter, M ;
Lehmann, AR ;
Hofmann, K ;
Dikic, I .
SCIENCE, 2005, 310 (5755) :1821-1824
[8]   Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics [J].
Bogliolo, Massimo ;
Surralles, Jordi .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2015, 33 :32-40
[9]   Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia [J].
Bogliolo, Massimo ;
Schuster, Beatrice ;
Stoepker, Chantal ;
Derkunt, Burak ;
Su, Yan ;
Raams, Anja ;
Trujillo, Juan P. ;
Minguillon, Jordi ;
Ramirez, Maria J. ;
Pujol, Roser ;
Casado, Jose A. ;
Banos, Rocio ;
Rio, Paula ;
Knies, Kerstin ;
Zuniga, Sheila ;
Benitez, Javier ;
Bueren, Juan A. ;
Jaspers, Nicolaas G. J. ;
Schaerer, Orlando D. ;
de Winter, Johan P. ;
Schindler, Detlev ;
Surralles, Jordi .
AMERICAN JOURNAL OF HUMAN GENETICS, 2013, 92 (05) :800-806
[10]   ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress [J].
Chen, Yu-Hung ;
Jones, Mathew J. K. ;
Yin, Yandong ;
Crist, Sarah B. ;
Colnaghi, Luca ;
Sims, Robert J., III ;
Rothenberg, Eli ;
Jallepalli, Prasad V. ;
Huang, Tony T. .
MOLECULAR CELL, 2015, 58 (02) :323-338
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