Pediatric angioedema: Essential features and preliminary results from the Hereditary Angioedema Global Registry in Italy

被引：8

作者：

Cancian, Mauro ^{[1
]}

Perego, Francesca ^{[2
]}

Senter, Riccardo ^{[1
]}

Arcoleo, Francesco ^{[3
]}

De Pasquale, Tiziana ^{[4
]}

Zoli, Alessandra ^{[5
]}

Cicardi, Marco ^{[2
,6
]}

Zanichelli, Andrea ^{[7
]}

机构：

[1] Univ Padua, Dept Med, Via Giustiniani 2, I-3526 Padua, Italy

[2] IRCCS Ist Clin Sci Maugeri, Milan, Italy

[3] Osped Riuniti Villa Sofia Cervello, Unita Operat Complessa Patol Clin, Palermo, Italy

[4] Civitanova Marche Hosp, Div Allergy, Civitanova Marche, Italy

[5] Osped Riuniti Ancona, Serv Immunol Clin & Tipizzaz Tessutale, Ancona, Italy

[6] Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, Milan, Italy

[7] A5ST Fatebenefratelli Sacco, Milan, Italy

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2020年 / 31卷

关键词：

C1-inhibitor; disease registry; hereditary angioedema; HGR; ITACA; pediatric; DEFICIENCY; MANAGEMENT; CONSENSUS; DIAGNOSIS;

D O I：

10.1111/pai.13170

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Isolated angioedema, which is a localized, non-pitting, and transient swelling of the subcutaneous or submucosal tissue not associated with pruritus, urticaria, or anaphylaxis, may be classified, based on genetic pattern and mediators, respectively, as acquired or hereditary and histamine- or non-histamine-induced. The pediatric population with C1-INH-HAE (Hereditary angioedema due to C1-inhibitor deficiency) is mostly symptomatic. The frequency of symptoms in such a population compared to adults seems to be lower, but we need more prospective data to conclude on this point. The HGR (Hereditary angioedema global registry), which collects symptoms in real time, will probably provide such information. In terms of treatments, pediatric patients are significantly disadvantaged due to the few studies aimed at registering treatment for this population.

引用

页码：22 / 24

页数：3

共 10 条

[1] Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency [J].

Bork, Konrad ;

Hardt, Jochen ;

Witzke, Guenther .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (03) :692-697

[2] Pathophysiology of Hereditary Angioedema [J].

Caccia, Sonia ;

Suffritti, Chiara ;

Cicardi, Marco .

PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY, 2014, 27 (04) :159-163

[3] Diagnostic and therapeutic management of hereditary angioedema due to C1-inhibitor deficiency: the Italian experience [J].

Cancian, Mauro .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 15 (04) :383-391

[4] Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group [J].

Cicardi, M. ;

Aberer, W. ;

Banerji, A. ;

Bas, M. ;

Bernstein, J. A. ;

Bork, K. ;

Caballero, T. ;

Farkas, H. ;

Grumach, A. ;

Kaplan, A. P. ;

Riedl, M. A. ;

Triggiani, M. ;

Zanichelli, A. ;

Zuraw, B. .

ALLERGY, 2014, 69 (05) :602-616

[5] Angioedema Due to Bradykinin Dysregulation [J].

Cicardi, Marco ;

Zuraw, Bruce L. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2018, 6 (04) :1132-1141

[6] International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency [J].

Farkas, H. ;

Martinez-Saguer, I. ;

Bork, K. ;

Bowen, T. ;

Craig, T. ;

Frank, M. ;

Germenis, A. E. ;

Grumach, A. S. ;

Luczay, A. ;

Varga, L. ;

Zanichelli, A. .

ALLERGY, 2017, 72 (02) :300-313

[7] The international WAO/EAACI guideline for the management of hereditary angioedema - the 2017 revision and update [J].

Maurer, Marcus ;

Magerl, Markus ;

Ansotegui, Ignacio ;

Aygoeren-Puersuen, Emel ;

Betschel, Stephen ;

Bork, Konrad ;

Bowen, Tom ;

Boysen, Henrik Balle ;

Farkas, Henriette ;

Grumach, Anete S. ;

Hide, Michihiro ;

Katelaris, Constance ;

Lockey, Richard ;

Longhurst, Hilary ;

Lumry, William R. ;

Martinez-Saguer, Inmaculada ;

Moldovan, Dumitru ;

Nast, Alexander ;

Pawankar, Ruby ;

Potter, Paul ;

Riedl, Marc ;

Ritchie, Bruce ;

Rosenwasser, Lanny ;

Sanchez-Borges, Mario ;

Zhi, Yuxiang ;

Zuraw, Bruce ;

Craig, Timothy .

WORLD ALLERGY ORGANIZATION JOURNAL, 2018, 11

[8] The Story of Angioedema: from Quincke to Bradykinin [J].

Reshef, Avner ;

Kidon, Mona ;

Leibovich, Iris .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2016, 51 (02) :121-139

[9] Abdominal attacks and treatment in hereditary angioedema with C1-inhibitor deficiency [J].

Rubinstein, Eitan ;

Stolz, Leslie E. ;

Sheffer, Albert L. ;

Stevens, Chris ;

Bousvaros, Athos .

BMC GASTROENTEROLOGY, 2014, 14

[10] A nationwide survey of hereditary angioedema due to C1 inhibitor deficiency in Italy [J].

Zanichelli, Andrea ;

Arcoleo, Francesco ;

Barca, Maria Pina ;

Borrelli, Paolo ;

Bova, Maria ;

Cancian, Mauro ;

Cicardi, Marco ;

Cillari, Enrico ;

De Carolis, Caterina ;

De Pasquale, Tiziana ;

Del Corso, Isabella ;

Di Rocco, Paola Cesinaro ;

Guarino, Maria Domenica ;

Massaro, Ilaria ;

Minale, Paola ;

Montinaro, Vincenzo ;

Neri, Sergio ;

Perricone, Roberto ;

Pucci, Stefano ;

Quattrocchi, Paolina ;

Rossi, Oliviero ;

Triggiani, Massimo ;

Zanierato, Giuseppina ;

Zoli, Alessandra .

ORPHANET JOURNAL OF RARE DISEASES, 2015, 10

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