Five new withanolides from Withania coagulans

被引：23

作者：

Atta-ur-Rahman ^{[1
]}

Yousaf, M

Gui, W

Qureshi, S

Choudhary, MI

Voelter, W

Hoff, A

Jens, F

Naz, A

机构：

[1] Univ Karachi, Hej Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

[2] Univ Tubingen, Phys Biochem Abt, Inst Physiol Chem, D-72076 Tubingen, Germany

来源：

HETEROCYCLES | 1998年 / 48卷 / 09期

关键词：

D O I：

10.3987/COM-98-8208

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phytochemical studies on the whole plant of Withania coagulans have resulted in the isolation of five new withanolides, namely coagulins H, I, J, K and L (1-5). Their structures have been established as (17S,20S,22R)-5 alpha,6 beta, 14 alpha, 15 alpha, 17,20-hexahydroxy-1-oxowitha-2,24-dienolide (1), (14R, 17S, 20S,22R)-5 alpha,6 beta,17-trihydroxy-14,20-epoxy-1-oxowitha-2,24-dienolide (2), (14R, 17R,20R,22R)-3 beta,27-dihydroxy-14,20-epoxy-1-oxowitha-5,24-dienolide (3), (14R, 17R,20R,22R)-14, 20-epoxy-3 beta-(O-beta-D-glucopyranosyl)-1-oxowitha-5,24-dienolide (4) and (14R, 17S,20S,22R)-14, 17,20-trihydroxy-3 beta-(O-beta-D-glucopyranosyl)-1-oxowitha-5,24-dienolide (5), respectively on the basis of spectroscopic techniques.

引用

页码：1801 / 1811

页数：11

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