Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

被引：9
作者：
Cardenas, Casimiro [1 ,2 ]
Antonio Torres-Vargas, Jose [1 ,3 ]
Cardenas-Valdivia, Abel [4 ]
Jurado, Nuria [1 ]
Quesada, Ana R. [1 ,3 ,5 ]
Garcia-Caballero, Melissa [1 ,3 ]
Martinez-Poveda, Beatriz [1 ,3 ,6 ]
Angel Medina, Miguel [1 ,3 ,5 ]
机构：
[1] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
[2] Univ Malaga, Res Support Cent Serv SCAI, Malaga, Spain
[3] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain
[4] Univ Malaga, Fac Sci, Dept Phys Chem, Malaga, Spain
[5] CIBER Enfermedades Raras CIBERER, E-29071 Malaga, Spain
[6] CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 144卷
关键词：
Ultra-high-performance liquid; chromatography-high-resolution mass spec-trometry(UHPLC-HRMS); Annona muricata; Graviola; Soursop; Angiogenesis; BREAST-CANCER CELLS; IN-VITRO; RING ACETOGENINS; ETHANOL EXTRACT; L; ANNONACEAE; FRUIT EXTRACT; LEAVES; GRAVIOLA; ANTIOXIDANT; IDENTIFICATION;
D O I：
10.1016/j.biopha.2021.112263
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
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页数：10
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