Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury

被引：37

作者：

Mukherjee, Nabanita ^{[1
]}

Nandi, Subhadra ^{[1
]}

Garg, Shubham ^{[1
]}

Ghosh, Satyajit ^{[1
]}

Ghosh, Surojit ^{[1
]}

Samat, Ramkamal ^{[1
]}

Ghosh, Surajit ^{[1
]}

机构：

[1] Indian Inst Technol Jodhpur, Dept Biosci & Bioengn, NH 65,Surpura Bypass Rd, Karwar 342037, Rajasthan, India

来源：

ACS CHEMICAL NEUROSCIENCE | 2020年 / 11卷 / 03期

关键词：

Central nervous system injury; axonal regeneration; glial scar; chondroitin sulfate proteoglycan; heparan sulfate proteoglycan; chondroitinase ABC enzyme;

D O I：

10.1021/acschemneuro.0c00004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar formed after severe traumatic brain injury as well as spinal cord injury and play a crucial inhibitory role in axonal regeneration by selective contraction of filopodia of the growth cone of sprouting neurites. Healing of central nervous system (CNS) injury requires degradation of the glycosamine glycan backbone of CSPGs in order to reduce the inhibitory effect of the CSPG layer. The key focus of this Viewpoint is to address a few important regenerative approaches useful for overcoming the inhibitory barrier caused by chondroitin sulfate proteoglycans.

引用

页码：231 / 232

页数：3

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