Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function

被引：70

作者：

Dutta, Arnob ^{[1
]}

Abmayr, Susan M. ^{[1
,2
]}

Workman, Jerry L. ^{[1
]}

机构：

[1] Stowers Inst Med Res, 1000 East 50th St, Kansas City, MO 64110 USA

[2] Univ Kansas, Dept Anat & Cell Biol, Med Ctr, Kansas City, KS 66160 USA

来源：

MOLECULAR CELL | 2016年 / 63卷 / 04期

关键词：

TATA-BINDING PROTEIN; SACCHAROMYCES-CEREVISIAE; ACETYLTRANSFERASE COMPLEXES; LYSINE PROPIONYLATION; KETONE-BODIES; YEATS DOMAIN; ADA COMPLEX; IN-VITRO; TRANSCRIPTION; ACETYLATION;

D O I：

10.1016/j.molcel.2016.06.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modifications of histones play important roles in balancing transcriptional output. The discovery of acyl marks, besides histone acetylation, has added to the functional diversity of histone modifications. Since all modifications use metabolic intermediates as substrates for chromatin-modifying enzymes, the prevalent landscape of histone modifications in any cell type is a snapshot of its metabolic status. Here, we review some of the current findings of how differential use of histone acylations regulates gene expression as response to metabolic changes and differentiation programs.

引用

页码：547 / 552

页数：6

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