Poly(ADP-ribose) polymerases as modulators of mitochondrial activity

被引：98

作者：

Bai, Peter ^{[1
,2
,3
]}

Nagy, Lille ^{[2
,3
]}

Fodor, Tamas ^{[2
,3
]}

Liaudet, Lucas ^{[4
,5
]}

Pacher, Pal ^{[6
]}

机构：

[1] Univ Debrecen, Res Ctr Mol Med, H-4012 Debrecen, Hungary

[2] MTA DE Lendulet Lab, Cellular Metab Res Grp, Debrecen, Hungary

[3] Univ Debrecen, Dept Med Chem, H-4012 Debrecen, Hungary

[4] Univ Lausanne Hosp, Med Ctr, Dept Intens Care Med, Lausanne, Switzerland

[5] Univ Lausanne Hosp, Med Ctr, Burn Ctr, Lausanne, Switzerland

[6] NIAAA, Lab Physiol Studies, Sect Oxidat Stress & Tissue Injury, NIH,DICBR, Bethesda, MD USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2015年 / 26卷 / 02期

关键词：

poly(ADP-ribose) polymerase; NAD(+); AMP activated kinase; Sirtuin; hypoxia-inducible factor; nuclear respiratory factor; INDUCIBLE FACTOR-I; NITRIC-OXIDE; CELL-DEATH; GLYCOHYDROLASE PARG; PARP-1; ACTIVATION; INHIBITION; SIRT1; BIOGENESIS; HYPERACTIVATION;

D O I：

10.1016/j.tem.2014.11.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitochondria are essential in cellular stress responses. Mitochondrial output to environmental stress is a major factor in metabolic adaptation and is regulated by a complex network of energy and nutrient sensing proteins. Activation of poly(ADP-ribose) polymerases (PARPs) has been known to impair mitochondrial function; however, our view of PARP-mediated mitochondrial dysfunction and injury has only recently fundamentally evolved. In this review, we examine our current understanding of PARP-elicited mitochondria! damage, PARP-mediated signal transduction pathways, transcription factors that interact with PARPs and govern mitochondrial biogenesis, as well as mitochondrial diseases that are mediated by PARPs. With PARP activation emerging as a common underlying mechanism in numerous pathologies, a better understanding the role of various PARPs in mitochondrial regulation may help open new therapeutic avenues.

引用

页码：75 / 83

页数：9

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