Ultrasound-assisted synthesis of pyrimidines and their fused derivatives: A review

被引：23

作者：

Mittersteiner, Mateus ^{[1
]}

Farias, Fellipe F. S. ^{[1
]}

Bonacorso, Helio G. ^{[1
]}

Martins, Marcos A. P. ^{[1
]}

Zanatta, Nilo ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, Nucleo Quim Heterociclos NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

ULTRASONICS SONOCHEMISTRY | 2021年 / 79卷

关键词：

Pyrimidines; Ultrasound; Synergic effects; Heterocycles; Catalysts; ONE-POT SYNTHESIS; ALKOXYVINYL TRIHALOMETHYL KETONES; DIVERSITY-ORIENTED SYNTHESIS; SULFAMIC ACID CATALYSIS; IONIC LIQUID; REGIOSELECTIVE SYNTHESIS; GREEN SYNTHESIS; BIGINELLI REACTION; MULTICOMPONENT SYNTHESIS; 3-COMPONENT SYNTHESIS;

D O I：

10.1016/j.ultsonch.2021.105683

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

The pyrimidine scaffold is present in many bioactive drugs; therefore, efficient synthetic routes that provide shorter reaction times, higher yields, and site-selective reactions are constantly being sought. Ultrasound (US) irradiation has emerged as an alternative energy source in the synthesis of these heterocyclic scaffolds, and over the last ten years there has been a significant increase in the number of publications mentioning US in either the construction or derivatization of the pyrimidine core. This review presents a detailed summary (with 140 ref-erences) of the effects of US (synergic or not) on the construction and derivatization of the pyrimidine core through classical reactions (e.g., multicomponent, cyclocondensation, cycloaddition, and alkylation reactions). The main points that were taken into consideration are as follows: chemo-and regioselectivity issues, and the results of conventional heating methods compared to US and mechanistic insights that are also presented and discussed for key reactions.

引用

页数：35

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[1] Magnetic nanoporous MCM-41 supported ionic liquid/palladium complex: An efficient nanocatalyst with high recoverability [J].