Immunity through DNA deamination

被引：181

作者：

Neuberger, MS ^{[1
]}

Harris, RS ^{[1
]}

Di Noia, J ^{[1
]}

Petersen-Mahrt, SK ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(03)00111-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional antibody genes assembled by V(D)J joining are subsequently diversified by somatic hypermutation, gene conversion and class-switch recombination. Recent evidence indicates that all three processes are caused by the deamination of cytosine to uracil at sites within the immunoglobulin (Ig) loci, with the pattern of diversification depending on the pathway used for resolving the initiating dU-dG lesion. Whereas DNA deamination targeted to the endogenous Ig locus triggers a program of somatic gene diversification that underpins adaptive immunity, deamination targeted to foreign DNA might have arisen initially as a form of innate immunity. Furthermore, the observation that members of the DNA deaminase family can target inappropriate genes suggests they might also contribute to mutations during genome evolution, as well as in cancer.

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收藏

页码：305 / 312

页数：8

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