Beta1-Adrenergic Receptor Regulation Revisited The Role of the Extracellular N-Terminus

被引：20
|
作者：
Steinberg, Susan F. [1 ]
机构：
[1] Columbia Univ, Dept Pharmacol, New York, NY USA
来源：
CIRCULATION RESEARCH | 2018年 / 123卷 / 11期
关键词：
apoptosis; arrestin; catecholamine; heart failure; immunoblotting; BETA(2)-ADRENERGIC RECEPTOR; TRANSGENIC MICE; HEART-FAILURE; BETA; HYPERTROPHY;
D O I：
10.1161/CIRCRESAHA.118.313884
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The actions and regulation of cardiomyocyte beta(1)ARs (beta(1) adrenergic receptors) differ in several respects from the properties described for the prototypical beta(2)AR subtype; a mechanism to explain the unique properties of the beta(1)AR subtype has never been obvious. This viewpoint summarizes recent studies that identify a novel signaling paradigm for the beta(1)AR, implicating the N terminus as a molecular determinant of beta(1)AR responsiveness.
引用
收藏
页码：1199 / 1201
页数：3
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