Visible-Light-Promoted Metal-Free C-H Trifluoromethylation of Imidazopyridines

被引：35

作者：

Mi, Xia ^{[1
]}

Kong, Yuanfang ^{[1
]}

Yang, Huaixia ^{[1
]}

Zhang, Jingyu ^{[1
]}

Pi, Chao ^{[2
]}

Cui, Xiuling ^{[2
]}

机构：

[1] Henan Univ Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China

[2] Zhengzhou Univ, Coll Chem, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem Henan Univ, Zhengzhou 450052, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 08期

基金：

中国国家自然科学基金;

关键词：

C-H trifluorometlylation; Photochemistry; Organocatalysis; Imidazopyridines; Radical reactions; Metal-free; CATALYTIC HYDROTRIFLUOROMETHYLATION; ALKENES; FUNCTIONALIZATION; IMIDAZOHETEROCYCLES; PERFLUOROALKYLATION; FLUORINE; DIFUNCTIONALIZATION; FLUOROALKYLATION; HETEROARENES; DESIGN;

D O I：

10.1002/ejoc.201901860

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free photo redox C-H trifluorometlylation of imidazopyridines is described. The reaction is operationally simple and the easy-handling CF3SO2Na serves as an effective fluoroalkyl radical precursor. Various functional groups were tolerated under blue LED light to access the desired products in satisfied yields at room temperature.

引用

页码：1019 / 1022

页数：4

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