Estimated glomerular filtration rate and functional status among older people: A systematic review

被引：12

作者：

Corsonello, Andrea ^{[1
]}

Roller-Wirnsberger, Regina ^{[2
]}

Di Rosa, Mirko ^{[1
]}

Fabbietti, Paolo ^{[1
]}

Wirnsberger, Gerhard ^{[2
]}

Kostka, Tomasz ^{[3
]}

Guligowska, Agnieszka ^{[3
]}

Tap, Lisanne ^{[4
]}

Mattace-Raso, Francesco ^{[4
]}

Gil, Pedro ^{[5
]}

Guardado-Fuentes, Lara ^{[5
]}

Meltzer, Itshak ^{[6
]}

Yehoshua, Ilan ^{[7
]}

Artzi-Medevdik, Rada ^{[6
,7
]}

Formiga, Francesc ^{[8
,9
]}

Moreno-Gonzalez, Rafael ^{[8
,9
]}

Weingart, Christian ^{[10
,11
]}

Freiberger, Ellen ^{[10
,11
]}

Arnlov, Johan ^{[12
,13
]}

Carlsson, Axel C. ^{[12
,14
]}

Lattanzio, Fabrizia ^{[1
]}

机构：

[1] INRCA Ancona, Ancona, Fermo & Cosenza, Italy

[2] Med Univ Graz, Dept Internal Med, Graz, Austria

[3] Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland

[4] Erasmus Univ, Med Ctr Rotterdam, Dept Internal Med, Sect Geriatr Med, Rotterdam, Netherlands

[5] Hosp Clin San Carlos, Dept Geriatr Med, Madrid, Spain

[6] Ben Gurion Univ Negev, Fac Hlth Sci, Recanati Sch Community Hlth Profess, Beer Sheva, Israel

[7] Maccabi Healthcare Serv Southern Reg, Tel Aviv, Israel

[8] Bellvitge Univ Hosp IDIBELL, Internal Med Dept, Geriatr Unit, Barcelona, Spain

[9] Bellvitge Univ Hosp IDIBELL, Nephrol Dept, Barcelona, Spain

[10] Friedrich Alexander Univ Erlangen Nurnberg, Krankenhaus Barmherzige Bruder Regensburg, Dept Gen Internal Med & Geriatr, Erlangen, Germany

[11] Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging, Erlangen, Germany

[12] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[13] Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden

[14] Karolinska Inst, Care Sci & Soc, Dept Neurobiol, Div Family Med, Huddinge, Sweden

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2018年 / 56卷

基金：

欧盟地平线“2020”;

关键词：

Estimated glomerular filtration rate (eGFR); Creatinine; Cystatin C; Frailty; Disability; CHRONIC KIDNEY-DISEASE; PHYSICAL PERFORMANCE; RENAL-FUNCTION; CYSTATIN-C; GENERAL-POPULATION; SERUM CREATININE; ELDERLY ADULTS; INCREASED RISK; UNITED-STATES; EQUATIONS;

D O I：

10.1016/j.ejim.2018.05.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The association between chronic kidney disease (CKD) and functional status may change as a function of the equation used to estimate glomerular filtration rate (eGFR). We reviewed the predictive value of different eGFR equations in regard to frailty and disability outcomes. Methods: We searched Pubmed from inception to March 2018 for studies investigating the association between eGFR and self-reported and/or objective measures of frailty or disability. Cross-sectional and longitudinal studies were separately analysed. Results: We included 16 studies, one of which reporting both cross-sectional and longitudinal data. Three out of 7 cross-sectional studies compared different eGFR equations in regard to their association with functional status: two studies showed that cystatin C-based, but not creatinine-based eGFR may be associated with hand-grip strength or frailty; another study showed that two different creatinine-based eGFR equations may be similarly associated with disability. Four out of 10 longitudinal studies provided comparative data: two studies reported similar association with disability for different creatinine-based eGFR equations; one study showed that creatinine-based eGFR was not associated with frailty, but a not significant trend for association was observed with cystatin C-based eGFR; one study showed that cystatin C-based but not creatinine-based eGFR may predict incident mobility disability, while both methods may predict gait speed decline. High heterogeneity was observed in regard to confounders included in reviewed studies. None of them included the most recently published equations. Conclusion: Available data do not support the superiority of one of the eGFR equations in terms of measuring or predicting functional decline.

引用

页码：39 / 48

页数：10

共 67 条

[1] Elevated blood urea, independent of glomerular filtration rate (GFR), confers increased risk of adverse functional outcome in elderly hip fracture patients [J].