Does ocular treatment of uveal melanoma influence survival?

被引：83

作者：

Damato, B. ^{[1
]}

机构：

[1] Royal Liverpool Univ Hosp, Ocular Oncol Serv, Liverpool L7 8XP, Merseyside, England

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 03期

关键词：

surgery; research; clinical trials; oncology; uveal melanoma; CHOROIDAL MELANOMA; MALIGNANT-MELANOMA; TUMOR PROGRESSION; METASTATIC DEATH; IRRADIATION; MORTALITY;

D O I：

10.1038/sj.bjc.6605765

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of uveal (intraocular) melanoma is aimed at prolonging life, if possible conserving the eye and useful vision. About 50% of patients develop fatal metastatic disease despite successful eradication of the primary intraocular tumour. The effect of ocular treatment on survival is unknown, because the same survival data from case series can be interpreted in different ways. Treatment is therefore based on intuition and varies greatly between centres. Randomised trials of treatment vs non-treatment of asymptomatic tumours are desirable but would be controversial, difficult, expensive and possibly inconclusive. Strategies for coping with uncertainty are needed to avoid unethical care. British Journal of Cancer (2010) 103, 285-290. doi:10.1038/sj.bjc.6605765 www.bjcancer.com (C) 2010 Cancer Research UK

引用

页码：285 / 290

页数：6

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