Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations

被引：20

作者：

Carretero, AS ^{[1
]}

Blanco, CC ^{[1
]}

Díaz, BC ^{[1
]}

Gutiérrez, AF ^{[1
]}

机构：

[1] Univ Granada, Dept Analyt Chem, Fac Sci, E-18071 Granada, Spain

来源：

ANALYST | 1998年 / 123卷 / 05期

关键词：

naphazoline; pharmaceutical analysis; room-temperature phosphorescence; micelle-stabilized luminescence; thallium heavy atom effect;

D O I：

10.1039/a708672e

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TlNO3) and a deoxygenation agent (Na2SO3). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml(-1) and a relative standard deviation of 3.74% at the 500 ng ml(-1) level. The method was applied to the analysis of pharmaceutical preparations.

引用

页码：1069 / 1071

页数：3

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