On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

被引：53

作者：

Lekki, J.

Stachura, Z.

Dabros, W.

Stachura, J.

Menzel, F.

Reinert, T.

Butz, T.

Pallon, J.

Gontier, E.

Ynsa, M. D.

Moretto, P.

Kertesz, Z.

Szikszai, Z.

Kiss, A. Z.

机构：

[1] Henryk Niewodniczanski Inst Nucl Phys PAN, PL-31342 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, PL-31008 Krakow, Poland

[3] Univ Leipzig, Fac Phys & Geowissensch, D-04103 Leipzig, Germany

[4] Lund Inst Technol, Dept Phys, Div Nucl Sci, S-22100 Lund, Sweden

[5] Ctr Etud Nucl Bordeaux Gradignan CNRS IN2P3, Gradignan, France

[6] Hungarian Acad Sci, Inst Nucl Res, H-4001 Debrecen, Hungary

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2007年 / 260卷 / 01期

关键词：

titanium dioxide; nanoparticles; skin penetration; ion microprobe; autoradiography;

D O I：

10.1016/j.nimb.2007.02.021

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：174 / 177

页数：4

共 10 条

[1]

Bennat C., 2000, International Journal of Cosmetic Science, V22, P271, DOI 10.1046/j.1467-2494.2000.00009.x

[2]

Forslind B, 1997, MICROSC RES TECHNIQ, V38, P373, DOI 10.1002/(SICI)1097-0029(19970815)38:4<373::AID-JEMT5>3.0.CO

[3]

2-K

[4]

GONTIER E, UNPUB

[5] Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice [J].

Lademann, J ;

Weigmann, HJ ;

Rickmeyer, C ;

Barthelmes, H ;

Schaefer, H ;

Mueller, G ;

Sterry, W .

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY, 1999, 12 (05) :247-256

[6]

LADEMANN J, BUND RIS BERL 28 3 2

[7] Microanalysis of the human skin structure: preliminary results [J].

Moretto, P ;

Surleve-Bazeille, JE ;

Licu, D ;

Michelet, C ;

Stoedzel, P .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1999, 158 (1-4) :386-392

[8]

Pfluecker F., 1999, International Journal of Cosmetic Science, V21, P399, DOI 10.1046/j.1467-2494.1999.211924.x

[9]

Tan M H, 1996, Australas J Dermatol, V37, P185

[10]

QLK4CT200202678

← 1 →