Macrophage heterogeneity and energy metabolism

被引：57
作者：
Verdeguer, Francisco [1 ,2 ]
Aouadi, Myriam [1 ]
机构：
[1] Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, KI AZ Integrated Cardio Metab Ctr, C2-84, S-14186 Stockholm, Sweden
[2] Univ Zurich, Dept Mol Mech Dis, Winterthurerstr 190, CH-8057 Zurich, Switzerland
来源：
EXPERIMENTAL CELL RESEARCH | 2017年 / 360卷 / 01期
基金：
瑞典研究理事会;
关键词：
Diabetes; Insulin resistance; Macrophage polarization; Metabolism; INSULIN-RESISTANCE; ADIPOSE-TISSUE; YOLK-SAC; LOCAL PROLIFERATION; HEPATIC STEATOSIS; ANALYSIS REVEALS; MYELOID CELLS; IKK-BETA; INFLAMMATION; OBESITY;
D O I：
10.1016/j.yexcr.2017.03.043
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Macrophages are versatile and multifunctional cell types present in most vertebrate tissues. They are the first line of defense against pathogens through phagocytosis of microbial infections, particles and dead cells. Macrophages harbor additional functions besides immune protection by participating in essential homeostatic and tissue development functions. The immune response requires a concomitant and coordinated regulation of the energetic metabolism. In this review, we will discuss how macrophages influence metabolic tissues and in turn how metabolic pathways, particularly glucose and lipid metabolism, affect macrophage phenotypes.
引用
收藏
页码：35 / 40
页数：6
相关论文
共 77 条
  • [1] Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation
    Amano, Shinya U.
    Cohen, Jessica L.
    Vangala, Pranitha
    Tencerova, Michaela
    Nicoloro, Sarah M.
    Yawe, Joseph C.
    Shen, Yuefei
    Czech, Michael P.
    Aouadi, Myriam
    [J]. CELL METABOLISM, 2014, 19 (01) : 162 - 171
  • [2] Aouadi M., 2014, AM J PHYSIOL-ENDOC M, V307, P83
  • [3] Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice
    Aouadi, Myriam
    Tencerova, Michaela
    Vangala, Pranitha
    Yawe, Joseph C.
    Nicoloro, Sarah M.
    Amano, Shinya U.
    Cohen, Jessica L.
    Czech, Michael P.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (20) : 8278 - 8283
  • [4] Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
    Aouadi, Myriam
    Tesz, Gregory J.
    Nicoloro, Sarah M.
    Wang, Mengxi
    Chouinard, My
    Soto, Ernesto
    Ostroff, Gary R.
    Czech, Michael P.
    [J]. NATURE, 2009, 458 (7242) : 1180 - U116
  • [5] IKK-β links inflammation to obesity-induced insulin resistance
    Arkan, MC
    Hevener, AL
    Greten, FR
    Maeda, S
    Li, ZW
    Long, JM
    Wynshaw-Boris, A
    Poli, G
    Olefsky, J
    Karin, M
    [J]. NATURE MEDICINE, 2005, 11 (02) : 191 - 198
  • [6] Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
    Avraham, Roi
    Haseley, Nathan
    Brown, Douglas
    Penaranda, Cristina
    Jijon, Humberto B.
    Trombetta, John J.
    Satija, Rahul
    Shalek, Alex K.
    Xavier, Ramnik J.
    Regev, Aviv
    Hung, Deborah T.
    [J]. CELL, 2015, 162 (06) : 1309 - 1321
  • [7] The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
    Bjorklund, Asa K.
    Forkel, Marianne
    Picelli, Simone
    Konya, Viktoria
    Theorell, Jakob
    Friberg, Danielle
    Sandberg, Rickard
    Mjosberg, Jenny
    [J]. NATURE IMMUNOLOGY, 2016, 17 (04) : 451 - +
  • [8] Regulation of immune responses by L- arginine metabolism
    Bronte, V
    Zanovello, P
    [J]. NATURE REVIEWS IMMUNOLOGY, 2005, 5 (08) : 641 - 654
  • [9] The TSC-mTOR pathway regulates macrophage polarization
    Byles, Vanessa
    Covarrubias, Anthony J.
    Ben-Sahra, Issam
    Lamming, Dudley W.
    Sabatini, David M.
    Manning, Brendan D.
    Horng, Tiffany
    [J]. NATURE COMMUNICATIONS, 2013, 4
  • [10] Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    Cai, DS
    Yuan, MS
    Frantz, DF
    Melendez, PA
    Hansen, L
    Lee, J
    Shoelson, SE
    [J]. NATURE MEDICINE, 2005, 11 (02) : 183 - 190
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