Locally administered nerve growth factor suppresses ginsenoside Rb1-enhanced peripheral nerve regeneration

被引：21

作者：

Tsai, CC ^{[1
]}

Lu, MC

Chen, YS

Wu, CH

机构：

[1] China Med Univ, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan

[2] China Med Univ, Inst Chinese Med Sci, Taichung, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2003年 / 31卷 / 05期

关键词：

nerve growth factor; ginsenoside Rb-1; nerve regeneration;

D O I：

10.1142/S0192415X03001387

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

A high-dose of nerve growth factor (NGF) mixed with ginsenoside Rb1 (GRb(1)) was encapsulated by collagen and placed in silicone rubber chambers, which were used to repair dissected Sprague-Dawley rat sciatic nerves with 15 mm gaps. Six weeks after surgery, no axons or Schwann cells were seen in these chambers. By comparison, nerves treated with collagen-GRb(1) alone had regenerated axons and Schwann cells in their endoneurial areas. We suggest that excessive NGF may not promote but, rather, suppress developing nerves.

引用

页码：665 / 673

页数：9

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