Locally administered nerve growth factor suppresses ginsenoside Rb1-enhanced peripheral nerve regeneration

被引：21

作者：

Tsai, CC ^{[1
]}

Lu, MC

Chen, YS

Wu, CH

机构：

[1] China Med Univ, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan

[2] China Med Univ, Inst Chinese Med Sci, Taichung, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2003年 / 31卷 / 05期

关键词：

nerve growth factor; ginsenoside Rb-1; nerve regeneration;

D O I：

10.1142/S0192415X03001387

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

A high-dose of nerve growth factor (NGF) mixed with ginsenoside Rb1 (GRb(1)) was encapsulated by collagen and placed in silicone rubber chambers, which were used to repair dissected Sprague-Dawley rat sciatic nerves with 15 mm gaps. Six weeks after surgery, no axons or Schwann cells were seen in these chambers. By comparison, nerves treated with collagen-GRb(1) alone had regenerated axons and Schwann cells in their endoneurial areas. We suggest that excessive NGF may not promote but, rather, suppress developing nerves.

引用

页码：665 / 673

页数：9

共 50 条

[31] Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression
Xiao, Hu
Wang, Dechang
Huo, Ran
Wang, Yibing
Feng, Yongqiang
Li, Qiang
[J]. NEURAL REGENERATION RESEARCH, 2013, 8 (17) : 1576 - 1581
[32] Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression
Hu Xiao
Dechang Wang
Ran Huo
Yibing Wang
Yongqiang Feng
Qiang Li
[J]. NeuralRegenerationResearch, 2013, 8 (17) : 1576 - 1581
[33] Enhanced peripheral nerve regeneration across silicone conduits using ultrashort-segment nerve grafts
Francel, PC
Francel, T
Hertl, C
MacKinnon, S
[J]. JOURNAL OF NEUROSURGERY, 1996, 84 (02) : 765 - 765
[34] Preparation and Characterization of Poly Lactic Acid/Graphene Oxide/Nerve Growth Factor Scaffold with Electrical Stimulation for Peripheral Nerve Regeneration in vitro
Xu, Haixing
Li, Rui
Li, Yiping
He, Qundi
Yan, Xiumei
Shu, Tao
Yang, Haixia
Lu, Yifei
Li, Zheng
Xu, Runtian
Xiong, Chengjie
Xu, Peihu
[J]. JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 2020, 35 (06): : 1149 - 1161
[35] Preparation and Characterization of Poly Lactic Acid/Graphene Oxide/Nerve Growth Factor Scaffold with Electrical Stimulation for Peripheral Nerve Regeneration in vitro
Haixing Xu
Rui Li
Yiping Li
Qundi He
Xiumei Yan
Tao Shu
Haixia Yang
Yifei Lü
Zheng Li
Runtian Xu
Chengjie Xiong
Peihu Xu
[J]. Journal of Wuhan University of Technology-Mater. Sci. Ed., 2020, 35 : 1149 - 1161
[36] Expression of nerve growth factor in the dorsal root ganglion after peripheral nerve injury
Lee, SE
Shen, H
Taglialatela, G
Chung, JM
Chung, K
[J]. BRAIN RESEARCH, 1998, 796 (1-2) : 99 - 106
[37] Effects of locally applied nerve growth factor to the inferior alveolar nerve histology in a rabbit model of mandibular distraction osteogenesis
Wang, L.
Zhao, Y.
Cheng, X.
Yang, Y.
Liu, G.
Ma, Q.
Shang, H.
Tian, L.
Lei, D.
[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2009, 38 (01) : 64 - 69
[38] Local administration of ciliary neurotrophic factor enhances peripheral nerve regeneration
Nobakhti-Afshar, A.
Raisi, A.
Mohammadi, R.
[J]. MINERVA ORTOPEDICA E TRAUMATOLOGICA, 2015, 66 (04) : 161 - 174
[39] Effect of recombinant human growth hormone on peripheral nerve regeneration: Experimental work on the ulnar nerve of the rat
Saceda, Javier
Isla, Alberto
Santiago, Susana
Morales, Carmen
Odene, Cristina
Hernandez, Borja
Deniz, Kenan
[J]. NEUROSCIENCE LETTERS, 2011, 504 (02) : 146 - 150
[40] TARGETED DELIVERY OF NERVE GROWTH-FACTOR VIA FIBRONECTIN CONDUITS ASSISTS NERVE REGENERATION IN CONTROL AND DIABETIC RATS
WHITWORTH, IH
TERENGHI, G
GREEN, CJ
BROWN, RA
STEVENS, E
TOMLINSON, DR
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1995, 7 (11) : 2220 - 2225

← 1 2 3 4 5 →