Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor

被引：15

作者：

Bag, Subhendu Sekhar ^{[1
]}

Pradhan, Manoj Kumar ^{[1
]}

Talukdar, Sangita ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Bioorgan Chem Lab, North Guwhati 781039, Assam, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 48期

关键词：

NUCLEIC-ACIDS; ABASIC SITE; DNA; BINDING; RECOGNITION; STABILITY; MECHANISM; SPECIFICITY; INHIBITION; SEQUENCE;

D O I：

10.1039/c7ob02433a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report herein the specific sensing of dimeric H45 G-quadruplex DNA via a fluorescence light-up response using fluorescent tetra-zolylpyrene nucleoside (B-TzPy(Do)) as a probe. The strong binding of the probe via an intercalative stacking interaction inside the connecting loop of two G-quadruplex units of H45 and the discrimination to other monomeric and long DNA duplexes are accompanied by a drastic enhancement of the emission intensity without compromising the conformation and stability.

引用

页码：10145 / 10150

页数：6

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