Blaschko lines and other patterns of cutaneous mosaicism

被引：71

作者：

Molho-Pessach, Vered ^{[1
]}

Schaffer, Julie V. ^{[1
]}

机构：

[1] NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY 10016 USA

来源：

CLINICS IN DERMATOLOGY | 2011年 / 29卷 / 02期

关键词：

X-CHROMOSOME INACTIVATION; PIGMENTARY MOSAICISM; EPIDERMAL NEVUS; HISTOPATHOLOGIC CHARACTERISTICS; PHYLLOID HYPOMELANOSIS; SOMATIC MUTATION; LICHEN-STRIATUS; SKIN; GENE; NEUROFIBROMATOSIS;

D O I：

10.1016/j.clindermatol.2010.09.012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches without midline separation, and lateralization. We emphasize the differential diagnoses, clues to correct categorization, and associated findings of inflammatory, hypopigmented, and hyperpigmented lesions with a mosaic distribution. Clinical examples are used to illustrate genetic concepts such as functional X-chromosome mosaicism, type 1 and 2 segmental manifestations of autosomal dominant skin diseases, paradominant inheritance, and twin spotting. (C) 2011 Published by Elsevier Inc.

引用

页码：205 / 225

页数：21

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