Quantitative ultrasound approaches for diagnosis and monitoring hepatic steatosis in nonalcoholic fatty liver disease

被引:123
作者
Pirmoazen, Amir M. [1 ]
Khurana, Aman [2 ]
El Kaffas, Ahmed [3 ]
Kamaya, Aya [1 ]
机构
[1] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA
[2] Univ Kentucky, Dept Radiol, Lexington, KY USA
[3] Stanford Univ, Sch Med, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA
来源
THERANOSTICS | 2020年 / 10卷 / 09期
基金
美国国家卫生研究院;
关键词
nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; quantitative ultrasound; noninvasive assessment; hepatic steatosis; CONTROLLED ATTENUATION PARAMETER; ACOUSTIC STRUCTURE QUANTIFICATION; DUAL-ENERGY CT; SOUND SPEED; TRANSIENT ELASTOGRAPHY; IN-VIVO; NONINVASIVE DIAGNOSIS; HEPATORENAL INDEX; SPECTRUM ANALYSIS; FIBROSIS SCORE;
D O I
10.7150/thno.40249
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nonalcoholic fatty liver disease is a major global health concern with increasing prevalence, associated with obesity and metabolic syndrome. Recently, quantitative ultrasound-based imaging techniques have dramatically improved the ability of ultrasound to detect and quantify hepatic steatosis. These newer ultrasound techniques possess many inherent advantages similar to conventional ultrasound such as universal availability, real-time capability, and relatively low cost along with quantitative rather than a qualitative assessment of liver fat. In addition, quantitative ultrasound-based imaging techniques are less operator dependent than traditional ultrasound. Here we review several different emerging quantitative ultrasound-based approaches used for detection and quantification of hepatic steatosis in patients at risk for nonalcoholic fatty liver disease. We also briefly summarize other clinically available imaging modalities for evaluating hepatic steatosis such as MRI, CT, and serum analysis.
引用
收藏
页码:4277 / 4289
页数:13
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