Oral lichen planus: malignant transformation and human papilloma virus: A review of potential clinical implications

被引：36

作者：

Gorsky, Meir ^{[1
]}

Epstein, Joel B. ^{[2
,3
]}

机构：

[1] Tel Aviv Univ, Maurice & Gabriela Goldschleger Sch Dent Med, Dept Oral Pathol & Oral Med, IL-69978 Tel Aviv, Israel

[2] Univ Illinois, Coll Dent, Dept Oral Med & Diagnost Sci, Dept Otolaryngol & Head & Neck Surg, Chicago, IL USA

[3] Univ Illinois, Coll Med, Ctr Canc, Chicago, IL USA

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2011年 / 111卷 / 04期

关键词：

SQUAMOUS-CELL CARCINOMA; EPITHELIAL DYSPLASIA; HPV DNA; LESIONS; HUMAN-PAPILLOMAVIRUS-18; MANAGEMENT; MUCOSA;

D O I：

10.1016/j.tripleo.2010.11.007

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Oral lichen planus (OLP) occurs in from 2% to 3% of the population and may have a risk of malignant transformation into squamous cell carcinoma (SCC). This risk is not necessarily associated with exposure to tobacco and alcohol. An increased awareness of a possible role of human papilloma virus (HPV) and SCC led us to review a possible association between this virus infection and malignant transformation of OLP. The possible linkage between HPV and the risk of transformation of OLP to malignancy is discussed. Furthermore, management of OLP using immunosuppressive drugs may be associated with enhanced viral replication and could theoretically affect the risk of malignant transformation. Implications for clinical care are discussed. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:461-464)

引用

页码：461 / 464

页数：4

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