A dual colorimetric-ratiometric fluorescent probe NAP-3 for selective detection and imaging of endogenous labile iron(III) pools in C. elegans

被引：64

作者：

Goel, Atul ^{[1
]}

Umar, Shahida ^{[1
]}

Nag, Pankaj ^{[1
]}

Sharma, Ashutosh ^{[1
]}

Kumar, Lalit ^{[2
]}

Shamsuzzama ^{[2
]}

Hossain, Zakir ^{[3
]}

Gayen, Jiaur R. ^{[3
]}

Nazir, Aamir ^{[2
]}

机构：

[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India

[2] CSIR, Cent Drug Res Inst, Dept Toxicol, Lucknow 226031, Uttar Pradesh, India

[3] CSIR, Cent Drug Res Inst, Dept Metab & Pharmacokinet, Lucknow 226031, Uttar Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 24期

关键词：

IRON LEVELS; CHEMOSENSOR; SENSORS; CELLS; FE3+; BLUE; FE2+;

D O I：

10.1039/c4cc09798j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The discovery of an iron(III)-selective ratiometric fluorescent probe to detect and visualize endogenous labile iron pools in living organisms at the molecular level has been long awaited. Herein we report the first dual colorimetric and ratiometric fluorescent probe naphtho[2,1-b]-[1,10] phenanthroline NAP-3 for selective and 'direct' visualization of labile iron(III) pools in a multicellular organism, Caenorhabditis elegans.

引用

页码：5001 / 5004

页数：4

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