Programming and reprogramming a human heart cell

被引：69

作者：

Sahara, Makoto ^{[1
,2
]}

Santoro, Federica ^{[1
]}

Chien, Kenneth R. ^{[1
,2
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden

[2] Karolinska Inst, Dept Med Cardiol, Stockholm, Sweden

来源：

EMBO JOURNAL | 2015年 / 34卷 / 06期

基金：

瑞典研究理事会;

关键词：

cardiac progenitor cell; cardiac regeneration; cardiomyocyte proliferation; embryonic heart field; reprogramming; CARDIAC STEM-CELLS; CHRONIC MYOCARDIAL-INFARCTION; MARROW MONONUCLEAR-CELLS; CARDIOSPHERE-DERIVED CELLS; TRANSCRIPTION FACTOR TBX3; CARDIOMYOCYTE-LIKE CELLS; OUTFLOW-TRACT SEPTATION; BONE-MARROW; PROGENITOR CELLS; ZEBRAFISH HEART;

D O I：

10.15252/embj.201490563

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The latest discoveries and advanced knowledge in the fields of stem cell biology and developmental cardiology hold great promise for cardiac regenerative medicine, enabling researchers to design novel therapeutic tools and approaches to regenerate cardiac muscle for diseased hearts. However, progress in this arena has been hampered by a lack of reproducible and convincing evidence, which at best has yielded modest outcomes and is still far from clinical practice. To address current controversies and move cardiac regenerative therapeutics forward, it is crucial to gain a deeper understanding of the key cellular and molecular programs involved in human cardiogenesis and cardiac regeneration. In this review, we consider the fundamental principles that govern the "programming" and "reprogramming" of a human heart cell and discuss updated therapeutic strategies to regenerate a damaged heart.

引用

页码：710 / 738

页数：29

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