Stevioside and Related Compounds - Molecules of Pharmaceutical Promise: A Critical Overview

被引：95
作者：
Brahmachari, Goutam [1 ]
Mandal, Lalan C. [1 ]
Roy, Rajiv [1 ]
Mondal, Sadhan [1 ]
Brahmachari, Arun K. [1 ]
机构：
[1] Visva Bharati Univ, Dept Chem, Lab Organ Synth & Nat Prod, Santini Ketan 731235, W Bengal, India
来源：
ARCHIV DER PHARMAZIE | 2011年 / 344卷 / 01期
关键词：
biosyntheses; clinical trials; ent-Kaurene glycosides; natural distributions; non-caloric sweeteners; pharmacological activities; safety evaluation; stevioside; structure-sweetness relationship; POTENTIAL SWEETENING AGENTS; DEOXYXYLULOSE PHOSPHATE-PATHWAY; BIFUNCTIONAL DITERPENE CYCLASE; STEVIA-REBAUDIANA BERTONI; PANCREATIC BETA-CELLS; ENZYMATIC TRANSGLUCOSYLATION; GLYCOSIDIC SWEETENERS; PLANT-ORIGIN; 2-STAGE CARCINOGENESIS; BACTERIAL EXPRESSION;
D O I：
10.1002/ardp.201000181
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Stevioside, an ent-kaurene type of diterpenoid glycoside, is a natural sweetener extracted from leaves of Stevia rebaudiana (Bertoni) Bertoni. Stevioside and a few related compounds are regarded as the most common active principles of the plant. Such phytochemicals have not only been established as noncaloric sweeteners, but reported to exhibit some other pharmacological activities also. In this article, natural distribution of stevioside and related compounds, their structural features, plausible biosynthetic pathways along with an insight into the structure sweetness relationship are presented. Besides, the pharmacokinetics, wide-range of pharmacological potentials, safety evaluation and clinical trials of these ent-kaurene glycosides are revisited.
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页码：5 / 19
页数：15
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