Background. The prognostic effect of visceral pleural invasion remains controversial when a tumor is less than 3 cm in stage I non-small cell lung cancer patients. We conducted this meta-analysis to evaluate the prognostic impact of visceral pleural invasion in these early patients. Methods. We searched PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure and included published studies on the prognostic significance of visceral pleural invasion in stage I non-small cell lung cancer. Meta-analysis was performed and heterogeneity and publication bias were also evaluated. Results. Twenty-two studies were included in the meta-analysis. In all stage I patients, visceral pleural invasion was associated with death (hazard ratio1.427; p = 0.000) and recurrence (hazard ratio1.600; p = 0.000). In subgroup analyses, visceral pleural invasions were consistently associated with death in each tumor size subgroup and recurrence in tumor less than 3 cm subgroup. Publication bias was not found. Conclusions. Visceral pleural invasion is a size-independent poor prognostic factor in stage I non-small cell lung cancer patients. We suggest adjuvant treatment should be considered in stage I patients with visceral pleural invasion. (C) 2015 by The Society of Thoracic Surgeons
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Travis, William D.
Brambilla, Elisabeth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Grenoble, Dept Pathol, Grenoble, FranceMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Brambilla, Elisabeth
Rami-Porta, Ramon
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Mutua de Terrassa, Dept Thorac Surg, Barcelona, SpainMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Rami-Porta, Ramon
Vallieres, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Swedish Canc Inst, Dept Thorac Surg, Seattle, WA USAMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Vallieres, Eric
Tsuboi, Masahiro
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Dept Thorac Surg, Tokyo, JapanMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Tsuboi, Masahiro
Rusch, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Thorac Surg, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Rusch, Valerie
Goldstraw, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Royal Brompton Hosp, Dept Thorac Surg, London, EnglandMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Travis, William D.
Brambilla, Elisabeth
论文数: 0引用数: 0
h-index: 0
机构:
Univ Grenoble, Dept Pathol, Grenoble, FranceMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Brambilla, Elisabeth
Rami-Porta, Ramon
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Mutua de Terrassa, Dept Thorac Surg, Barcelona, SpainMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Rami-Porta, Ramon
Vallieres, Eric
论文数: 0引用数: 0
h-index: 0
机构:
Swedish Canc Inst, Dept Thorac Surg, Seattle, WA USAMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Vallieres, Eric
Tsuboi, Masahiro
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Dept Thorac Surg, Tokyo, JapanMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Tsuboi, Masahiro
Rusch, Valerie
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Dept Thorac Surg, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
Rusch, Valerie
Goldstraw, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Royal Brompton Hosp, Dept Thorac Surg, London, EnglandMem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA