Visceral Pleural Invasion Remains a Size-Independent Prognostic Factor in Stage I Non-Small Cell Lung Cancer

被引:72
作者
Huang, He
Wang, Ting [1 ]
Hu, Bin
Pan, Changchuan
机构
[1] Sichuan Canc Hosp, Dept Med Oncol, Chengdu 610041, Peoples R China
关键词
RISK-FACTORS; 7TH EDITION; 3; CM; TNM CLASSIFICATION; RECURRENCE; SURVIVAL; IMPACT; ADENOCARCINOMA; DIAMETER; REEVALUATION;
D O I
10.1016/j.athoracsur.2014.11.052
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. The prognostic effect of visceral pleural invasion remains controversial when a tumor is less than 3 cm in stage I non-small cell lung cancer patients. We conducted this meta-analysis to evaluate the prognostic impact of visceral pleural invasion in these early patients. Methods. We searched PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure and included published studies on the prognostic significance of visceral pleural invasion in stage I non-small cell lung cancer. Meta-analysis was performed and heterogeneity and publication bias were also evaluated. Results. Twenty-two studies were included in the meta-analysis. In all stage I patients, visceral pleural invasion was associated with death (hazard ratio1.427; p = 0.000) and recurrence (hazard ratio1.600; p = 0.000). In subgroup analyses, visceral pleural invasions were consistently associated with death in each tumor size subgroup and recurrence in tumor less than 3 cm subgroup. Publication bias was not found. Conclusions. Visceral pleural invasion is a size-independent poor prognostic factor in stage I non-small cell lung cancer patients. We suggest adjuvant treatment should be considered in stage I patients with visceral pleural invasion. (C) 2015 by The Society of Thoracic Surgeons
引用
收藏
页码:1130 / 1139
页数:10
相关论文
共 38 条
  • [31] Padilla J, 1997, ANN THORAC SURG, V63, P324
  • [32] The IASLC lung cancer staging project:: Proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer
    Rami-Porta, Ramon
    Ball, David
    Crowley, John
    Giroux, Dorothy J.
    Jett, James
    Travis, William D.
    Tsuboi, Masahiro
    Vallieres, Eric
    Goldstraw, Peter
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (07) : 593 - 602
  • [33] Visceral pleural invasion is an invasive and aggressive indicator of non-small cell lung cancer
    Shimizu, K
    Yoshida, J
    Nagai, K
    Nishimura, M
    Ishii, G
    Morishita, Y
    Nishiwaki, Y
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2005, 130 (01) : 160 - 165
  • [34] Sobin LH, 2009, TNM CLASSIFICATION M
  • [35] Impact of elastic staining on the staging of peripheral lung cancers
    Taube, Janis M.
    Askin, Frederic B.
    Brock, Malcolm V.
    Westra, William
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (06) : 953 - 956
  • [36] Practical methods for incorporating summary time-to-event data into meta-analysis
    Tierney, Jayne F.
    Stewart, Lesley A.
    Ghersi, Davina
    Burdett, Sarah
    Sydes, Matthew R.
    [J]. TRIALS, 2007, 8 (1)
  • [37] Visceral Pleural Invasion: Pathologic Criteria and Use of Elastic Stains Proposal for the 7th Edition of the TNM Classification for Lung Cancer
    Travis, William D.
    Brambilla, Elisabeth
    Rami-Porta, Ramon
    Vallieres, Eric
    Tsuboi, Masahiro
    Rusch, Valerie
    Goldstraw, Peter
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2008, 3 (12) : 1384 - 1390
  • [38] Prognostic impact and initial recurrence site of lymphovascular and visceral pleural invasion in surgically resected stage I non-small-cell lung carcinoma
    Yanagawa, Naoki
    Shiono, Satoshi
    Abiko, Masami
    Ogata, Shin-ya
    Sato, Toru
    Tamura, Gen
    [J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2013, 44 (03) : E200 - E206