An efficient route to 4-(substituted benzyl)piperidines

被引：20

作者：

Furman, B ^{[1
]}

Dziedzic, M ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 45期

关键词：

cyclisation; piperidines; Heck reaction;

D O I：

10.1016/j.tetlet.2003.09.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel approach to 4-(substituted benzyl)piperidines has been developed. The key steps involve the cyclization of imines bearing an allylsilane in the side-chain followed by the palladium-catalyzed cross-coupling of the resulting 4-methylenepiperidine with organoboronic acids under an atmosphere of oxygen. (C) 2003 Published by Elsevier Ltd.

引用

页码：8249 / 8252

页数：4

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