Demographic and clinical characteristics of pulmonary arterial hypertension caused by schistosomiasis are indistinguishable from other etiologies

被引:6
作者
Mendes, Adriano Assis [1 ]
Piscoya Roncal, Carlos Guilhermo [1 ,3 ]
Azevedo de Oliveira, Flavio Roberto [2 ]
de Albuquerque, Eugenio Soares [3 ]
Belarmino Goes, Gustavo Henrique [4 ]
de Vasconcellos Piscoya, Isabelle Cecilia [4 ]
Sobral Filho, Dario Celestino [5 ]
机构
[1] Univ Pernambuco, Dept Hipertensao Pulm, Prontosocorro Cardiol Pernambuco, Recife, PE, Brazil
[2] Univ Pernambuco, Dept Hemodinam, Recife, PE, Brazil
[3] Univ Pernambuco, Dept Ecocardiog, Recife, PE, Brazil
[4] Univ Pernambuco, Fac Ciencias Med, Recife, PE, Brazil
[5] Univ Pernambuco, Programa Posgrad Ciencias Saude, Recife, PE, Brazil
关键词
Pulmonary hypertension; Schistosomiasis; Cardiopulmonary disease; Heart failure; Right ventricle; SURVIVAL; REGISTRY; CATHETERIZATION; PREVALENCE; GUIDELINES; DIAGNOSIS; PRESSURE;
D O I
10.1590/0037-8682-0418-2019
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Introduction: Pulmonary arterial hypertension (PAH) is a serious pulmonary circulation disease caused by several etiologies, including schistosomiasis. The present study retrospectively evaluated the clinical and hemodynamic characteristics of patients with schistosomal PAH (PAH-Sch) compared to those of non-Sch PAH patients (non-Sch PAH). Methods: Patients treated at the Pronto-Socorro Cardiologico de Pernambuco and diagnosed by right cardiac catheterization were divided into PAH-Sch and non-Sch PAH groups. Their socio-demographic and clinical characteristics, N-terminal-pro B-type natriuretic peptide (NT-proBNP), and echocardiograplry and hemodynamic parameters were retrospectively reviewed. Results: Among the included 98 patients (mean age, 45 +/- 14 years; 68 women [69.4%]), we found 56 PAH-Sch and 42 non-Sch PAH. The age distribution was heterogeneous in the PAH-Sch group, with patients predominantly ranging from 50-59 (p <0.004). Dyspnea was the most common symptom, reported by 92 patients (93.8%), and commonly present for over two years prior to diagnosis. Clinical symptoms were similar in both groups, with no differences in functional class, pulmonary artery systolic pressure (p = 0.102), 6-minute walk test score (p = 0.234), NT-proBNP serum levels (p = 0.081), or hemodynamic parameters. Conclusions: Patients with PAH-Sch present clinical, laboratory, and hemodynamic profiles similar to those with PAH resulting from other etiologies of poor prognosis. PAH is an important manifestation of schistosomiasis in endemic regions that is often diagnosed late.
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