Silica/Polyethylene Glycol Hybrid Materials Prepared by a Sol-Gel Method and Containing Chlorogenic Acid

被引:22
|
作者
Catauro, Michelina [1 ]
Tranquillo, Elisabetta [1 ,2 ]
Salzillo, Alessia [2 ]
Capasso, Lucia [2 ]
Illiano, Michela [2 ]
Sapio, Luigi [2 ]
Naviglio, Silvio [2 ]
机构
[1] Univ Campania Luigi Vanvitelli, Dept Engn, Via Roma 29, I-81031 Aversa, Italy
[2] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L De Crecchio 7, I-80138 Naples, Italy
来源
MOLECULES | 2018年 / 23卷 / 10期
关键词
sol-gel method; natural compounds; cell proliferation; DRUG-DELIVERY; OXIDATIVE STRESS; DOXORUBICIN; SENSITIVITY; MECHANISM; APOPTOSIS; SURFACE; CELLS; FILMS;
D O I
10.3390/molecules23102447
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chlorogenic acid (CGA) is a very common dietary polyphenolic compound. CGA is becoming very attractive due to its potential use as preventive and therapeutic agent in many diseases, including cancer. Inorganic/organic hybrid materials are gaining considerable attention in the biomedical field. The sol-gel process provides a useful way to obtain functional organic/inorganic hybrids. The aim of this study was to synthesize silica/polyethylene glycol (PEG) hybrids with different percentages of CGA by sol-gel technique and to investigate their impact on the cancer cell proliferation. Synthesized materials have been chemically characterized through the FTIR spectroscopy and their bioactivity evaluated looking by SEM at their ability to produce a hydroxyapatite layer on their surface upon incubation with simulated body fluid (SBF). Finally, their effects on cell proliferation were studied in cell lines by direct cell number counting, MTT, flow cytometry-based cell-cycle and cell death assays, and immunoblotting experiments. Notably, we found that SiO2/PEG/CGA hybrids exhibit clear antiproliferative effects in different tumor, including breast cancer and osteosarcoma, cell lines in a CGA dependent manner, but not in normal cells. Overall, our results increase the evidence of CGA as a possible anticancer agent and illustrate the potential for clinical applications of sol-gel synthesized SiO2/PEG/CGA materials.
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页数:15
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