β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching

被引：51
作者：
Enshell-Seijffers, David [1 ,2 ]
Lindon, Catherine [1 ,2 ]
Wu, Eleanor [1 ,2 ]
Taketo, Makoto M. [3 ]
Morgan, Bruce A. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
[2] Massachusetts Gen Hosp, Charlestown, MA 02129 USA
[3] Kyoto Univ, Grad Sch Med, Dept Pharmacol, Sakyo Ku, Kyoto 6068501, Japan
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 50期
关键词：
pheomelanin; eumelanin; MOUSE AGOUTI GENE; COAT-COLOR; DOMESTIC DOGS; MICE; MUTATION; ATTRACTIN; PROTEIN; EXPRESSION; MELANISM; PATHWAY;
D O I：
10.1073/pnas.1007326107
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The switch between black and yellow pigment is mediated by the interaction between Melanocortin receptor 1 (Mc1r) and its antagonist Agouti, but the genetic and developmental mechanisms that modify this interaction to obtain different coat color in distinct environments are poorly understood. Here, the role of Wnt/beta-catenin signaling in the regulation of pigment-type switching was studied. Loss and gain of function of beta-catenin in the dermal papilla (DP) of the hair follicle results in yellow and black animals, respectively. beta-Catenin activity in the DP suppresses Agouti expression and activates Corin, a negative regulator of Agouti activity. In addition, beta-catenin activity in the DP regulates melanocyte activity by a mechanism that is independent of both Agouti and Corin. The coordinate and inverse regulation of Agouti and Corin renders pelage pigmentation sensitive to changes in beta-catenin activity in the DP that do not alter pelage structure. As a result, the signals that specify two biologically distinct quantitative traits are partially uncoupled despite their common regulation by the beta-catenin pathway in the same cells.
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收藏
页码：21564 / 21569
页数：6
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