Studies towards the Total Synthesis of Kadcotrione B

被引：3

作者：

Reddy, Julakanti Satyanarayana ^{[1
]}

Gangababu, Marri ^{[1
]}

Manimala, Patel ^{[1
]}

Rammohan, Aluru ^{[1
,2
]}

Yadav, Jillu Singh ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Telangana, India

[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 05期

关键词：

aldol condensation; diastereoselectivity; Hagiwara-Weiland-Miescher ketone; Horner-Wadsworth-Emmons reaction; Kadcotrione; Michael addition; ENANTIOSELECTIVE SYNTHESIS; ABSOLUTE-CONFIGURATION; SCHISANDRA; ACID; TRITERPENOIDS; CYCLIZATION; OXIDATION; LIBRARY; STEREO; FAMILY;

D O I：

10.1055/s-0039-1691494

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensation, Evans aldol reaction, Horner-Wadsworth-Emmons olefination, Michael addition, Robinson annulation, and Wacker oxidation.

引用

页码：735 / 743

页数：9

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