Studies towards the Total Synthesis of Kadcotrione B

被引：3
|
作者：
Reddy, Julakanti Satyanarayana [1 ]
Gangababu, Marri [1 ]
Manimala, Patel [1 ]
Rammohan, Aluru [1 ,2 ]
Yadav, Jillu Singh [1 ]
机构：
[1] CSIR Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Telangana, India
[2] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India
来源：
SYNTHESIS-STUTTGART | 2020年 / 52卷 / 05期
关键词：
aldol condensation; diastereoselectivity; Hagiwara-Weiland-Miescher ketone; Horner-Wadsworth-Emmons reaction; Kadcotrione; Michael addition; ENANTIOSELECTIVE SYNTHESIS; ABSOLUTE-CONFIGURATION; SCHISANDRA; ACID; TRITERPENOIDS; CYCLIZATION; OXIDATION; LIBRARY; STEREO; FAMILY;
D O I：
10.1055/s-0039-1691494
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensation, Evans aldol reaction, Horner-Wadsworth-Emmons olefination, Michael addition, Robinson annulation, and Wacker oxidation.
引用
收藏
页码：735 / 743
页数：9
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