HSP70 induction by bleomycin metal core analogs

被引：2

作者：

Ali, Taha F. S. ^{[1
,2
]}

Taira, Naomi ^{[1
]}

Iwamaru, Kana ^{[1
]}

Koga, Ryoko ^{[1
]}

Kamo, Masahiro ^{[1
]}

Radwan, Mohamed O. ^{[1
]}

Tateishi, Hiroshi ^{[1
]}

Kurosaki, Hiromasa ^{[3
]}

Abdel-Aziz, Mohamed ^{[2
]}

Abuo-Rahma, Gamal El-Din A. A. ^{[2
]}

Beshr, Eman A. M. ^{[2
]}

Otsuka, Masami ^{[1
,4
]}

Fujita, Mikako ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Life Sci, Med & Biol Chem Sci Farm Joint Res Lab, Chuo Ku, 5-1 Oe Honmachi, Kumamoto, Kumamoto 8620973, Japan

[2] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt

[3] Kinjo Gakuin Univ, Coll Pharm, Moriyama Ku, 2-1723 Omori, Nagoya, Aichi 4638521, Japan

[4] Sci Farm Ltd, Dept Drug Discovery, Chuo Ku, 1-7-30 Kuhonji, Kumamoto, Kumamoto 8620976, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2020年 / 30卷 / 07期

关键词：

HSP70; induction; Metal chelator; Bleomycin; PC-12; cells; GASTRIC-MUCOSAL CELLS; HEAT-SHOCK PROTEINS; T-LYMPHOCYTES; MODEL; HEAT-SHOCK-PROTEIN-70; SUPPRESSION; CHAPERONES; INHIBITOR; MECHANISM; PROTECTS;

D O I：

10.1016/j.bmcl.2020.127002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Induction of heat shock protein 70 (HSP70) is known to be effective against various diseases. We are interested in HSP70 induction capability of an antitumor antibiotic bleomycin which produces oxidative stress by iron chelate formation and oxygen activation in a cell. The HSP70 induction activity of bleomycin and its six metal core analogs was examined, and a compound HPH-1Trt of 10 mu M was found to induce this protein in a pheochromocytoma cell line and some T cell and monocytic cell lines. Its mechanism is increase of HSP70 mRNA, but higher concentration of this compound showed toxicity. Two new derivatives were then synthesized, and one of them named DHPH-1Trt was shown to have less toxicity and higher HSP70 induction activity. This study would lead to a clue for new HSP70 inducer clinically used in near future.

引用

页数：7

共 36 条

[1] Protective mechanism of gallic acid and its novel derivative against ethanol-induced gastric ulcerogenesis: Involvement of immunomodulation markers, Hsp70 and Bcl-2-associated X protein
Abdelwahab, Siddig Ibrahim
[J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2013, 16 (02) : 296 - 305
[2] Induction of the hsp70 gene promoter by various anticancer drugs
Aït-Aïssa, S
Porcher, JM
Kretz-Remy, C
Velarde, G
Arrigo, AP
Lambre, C
[J]. TOXICOLOGY IN VITRO, 1999, 13 (4-5) : 651 - 655
[3] Induction of apoptosis in Herpesvirus saimiri-immortalized T lymphocytes by blocking interaction of CD28 with CD80/CD86
Akari, H
Fukumori, T
Iida, S
Adachi, A
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 263 (02) : 352 - 356
[4] Effects of SIVmac infection on peripheral blood CD4+CD8+ T lymphocytes in cynomolgus macaques
Akari, H
Nam, KH
Mori, K
Otani, I
Shibata, H
Adachi, A
Terao, K
Yoshikawa, Y
[J]. CLINICAL IMMUNOLOGY, 1999, 91 (03) : 321 - 329
[5] New SIRT2 inhibitors: Histidine-based bleomycin spin-off
Ali, Taha F. S.
Ciftci, Halil I.
Radwan, Mohamed O.
Koga, Ryoko
Ohsugi, Takeo
Okiyama, Yoshio
Honma, Teruki
Nakata, Akiko
Ito, Akihiro
Yoshida, Minoru
Fujita, Mikako
Otsuka, Masami
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (09) : 1767 - 1775
[6] Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system
Ali, Taha F. S.
Iwamaru, Kana
Ciftci, Halil Ibrahim
Koga, Ryoko
Matsumoto, Masahiro
Oba, Yasunori
Kurosaki, Hiromasa
Fujita, Mikako
Okamoto, Yoshinari
Umezawa, Kazuo
Nakao, Mitsuyoshi
Hide, Takuichiro
Makino, Keishi
Kuratsu, Jun-ichi
Abdel-Aziz, Mohamed
Abuo-Rahma, Gamal El-Din A. A.
Beshr, Eman A. M.
Otsuka, Masami
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (17) : 5476 - 5482
[7] Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
Auluck, PK
Chan, HYE
Trojanowski, JQ
Lee, VMY
Bonini, NM
[J]. SCIENCE, 2002, 295 (5556) : 865 - 868
[8] Chatterjee S, 2017, INT J MOL SCI, V18
[9] Bleomycins: Towards better therapeutics
Chen, JY
Stubbe, J
[J]. NATURE REVIEWS CANCER, 2005, 5 (02) : 102 - 112
[10] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR
GREENE, LA
TISCHLER, AS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) : 2424 - 2428

← 1 2 3 4 →