Dilemmas in Treating Smoldering Multiple Myeloma

被引：18

作者：

Ahn, Inhye E. ^{[1
]}

Mailankody, Sham ^{[1
]}

Korde, Neha ^{[2
]}

Landgren, Ola ^{[2
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 33卷 / 01期

基金：

美国国家卫生研究院;

关键词：

STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; MULTIPARAMETER FLOW-CYTOMETRY; GENE-EXPRESSION SIGNATURE; MONOCLONAL GAMMOPATHY; HIGH-RISK; PROGNOSTIC-SIGNIFICANCE; MELPHALAN-PREDNISONE; PLUS DEXAMETHASONE; ZOLEDRONIC ACID;

D O I：

10.1200/JCO.2014.56.4351

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Novel therapies hold promise for high-risk smoldering multiple myeloma (SMM). Recent studies suggest that modern combination approaches can be options for high-risk SMM to obtain deep molecular responses with favorable toxicity profiles. Although pioneering treatment trials based on small numbers of patients suggest progression-free and overall survival benefits, application of the data to real-life practice remains to be validated. Therapeutic modulation of disease tempo, disease burden, clonal evolution, and tumor microenvironment in SMM remains to be understood and calls for reliable biomarkers reflective of disease biology. Here, we review studies that open a new management platform for SMM, address ongoing dilemmas in practice and under investigation, and highlight emerging scientific questions in the era of SMM treatment. (C) 2014 by American Society of Clinical Oncology

引用

页码：115 / U178

页数：10

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