Bone metastases of differentiated thyroid cancer:: Impact of early 131I-based detection on outcome

Bone is the second most frequent target of distant metastases in patients with differentiated thyroid cancer, and such forms carry a very poor prognosis. The impact of I-131 therapy in this setting is controversial. We describe the diagnostic circumstances and outcome of patients with bone metastases recently managed in two institutions. Among 921 consecutive thyroid cancer patients who had total thyroidectomy and I-131 ablation between January 2000 and December 2004 and who were subsequently monitored, bone metastases had been diagnosed in 16 patients. In three cases, the bone metastases were non-functioning (negative I-131 uptake). These patients were treated with surgery and radiotherapy but progressed rapidly. The other 13 patients had functioning (positive I-131 uptake) bone metastases. In five of them, thyroid cancer was revealed by signs of distant involvement (bone pain, n=4; dyspnea, n=1). The bone metastases progressed in these five patients, despite local therapy and multiple courses of I-131. The bone metastases in the remaining eight patients were discovered on the postsurgery I-131 therapy scan. Complementary radiological studies were negative except in one patient in whom one of the metastases (a 5 mm lesion of the right humerus) was visible on magnetic resonance imaging (MRI). Six of these patients showed a good response to I-131 therapy, with I-131 uptake and Tg levels becoming undetectable or showing a sharp fall. One patient refused I-131 therapy; bone metastases became visible on MRI within 1 year and the Tg level rose tenfold. The disease progressed in one patient despite I-131 therapy. Post-surgical I-131 ablation can contribute to early detection of bone metastases at a time when the Tg level may be only moderately elevated, when other radiological studies are negative, and when the disease is potentially curable by I-131 therapy.