Impact of age on early outcomes and long-term survival of patients undergoing aortic repair with Stanford A dissection

被引:2
作者
Merkle, Julia [1 ]
Sabashnikov, Anton [1 ]
Weber, Carolyn [1 ]
Schlachtenberger, Georg [1 ]
Maier, Johanna [1 ]
Spieker, Anna [1 ]
Eghbalzadeh, Kaveh [1 ]
Deppe, Antje-Christin [1 ]
Zeriouh, Mohamed [1 ]
Rahmanian, Parwis B. [1 ]
Madershahian, Navid [1 ]
Rustenbach, Christian [1 ]
Choi, Yeong-Hoon [1 ]
Kuhn-Regnier, Ferdinand [1 ]
Liakopoulos, Oliver [1 ]
Wahlers, Thorsten [1 ]
机构
[1] Univ Hosp Cologne, Dept Cardiothorac Surg, Kerpener Str 62, D-50937 Cologne, Germany
来源
PERFUSION-UK | 2018年 / 33卷 / 08期
关键词
Stanford A acute aortic dissection; age; short-term and long-term survival; SURGICAL OUTCOMES; SEX-DIFFERENCES; A DISSECTION; SURGERY; MANAGEMENT; MORTALITY; GENDER; RISK; REGISTRY;
D O I
10.1177/0267659118786332
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Stanford A acute aortic dissection (AAD) is a life-threatening emergency, typically occurring in older patients and requiring immediate surgical repair. The aim of this study was to evaluate early outcome and short- and long-term survival of patients under and above 65 years of age. Methods: Two hundred and forty patients with Stanford A AAD underwent aortic surgical repair from January 2006 to April 2015 in our center. After statistical analysis and logistic regression analysis, Kaplan-Meier survival estimation was performed, with up to 9-year follow-up, comprising patients under and above 65 years of age. Results: The proportion of patients above 65 years of age suffering from Stanford A AAD was 50% (n=120). The group of patients above 65 years of age compared to the group under 65 years of age showed statistically significant differences in terms of higher odds ratios (OR) for hypertension (p=0.012), peripheral vascular disease (p=0.026) and tachyarrhythmia absoluta (p=0.004). Patients over 65 years of age also showed significantly poorer short- and long-term survival. Our subgroup analysis revealed that male patients (Breslow p=0.001, Log-Rank p=0.001) and patients suffering with hypertension (Breslow p=0.003, Log-Rank p=0.001) were reasonable for these results whereas younger and older female patients showed similar short- and long-term outcome (Breslow p=0.926, Log-Rank p=0.724). After stratifying all patients into 4 age groups (75years), short-term survival of the patients appeared to be significantly poorer with increasing age (Breslow p=0.026, Log-Rank p=0.008) whereas long-term survival of patients free from cerebrovascular events (Breslow p=0.0494, Log-Rank p=0.489) remained similar. Conclusions: All patients referred to our hospital for repair of Stanford A AAD with higher age had poorer short- and long-term survival, caused by male patients and patients suffering from hypertension, whereas survival of women and survival free from cerebrovascular events of the entire patient cohort was similar, irrespective of age.
引用
收藏
页码:687 / 695
页数:9
相关论文
共 50 条
[41]   Impact of Lymphocyte-Related Blood Parameters on Short- and Long-Term Outcomes of Patients Undergoing Thoracic Endovascular Aortic Repair [J].
Yang, Fan ;
Liu, Jitao ;
Chen, Lyufan ;
Fan, Ruixin ;
Zeng, Hongke ;
Geng, Qingshan ;
Luo, Jianfang .
ANGIOLOGY, 2021, 72 (10) :953-960
[42]   Short- and long-term survival after isolated coronary artery bypass grafting, the impact of gender and age [J].
Nuru, A. ;
Weltzien, J. A. H. ;
Sandvik, L. ;
Tonnessen, T. ;
Bjornstad, J. L. .
SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2019, 53 (06) :342-347
[43]   Risk Factors Associated with Poor Prognosis in Patients with Stanford Type B Aortic Dissection after Thoracic Endovascular Aortic Repair [J].
Wang, Shuangjing ;
Jia, Heyue ;
Xi, Yifu ;
Yuan, Pengfei ;
Wu, Mingwei ;
Ren, Luxia ;
Guo, Wei ;
Xiong, Jiang .
ANNALS OF VASCULAR SURGERY, 2023, 93 :122-127
[44]   The impact of age and sex on in hospital outcomes in acute type A aortic dissection surgery [J].
Morjan, Mohammed ;
Mestres, Carlos A. ;
Lavanchy, Isabel ;
Gercek, Mustafa ;
Van Hemelrijck, Mathias ;
Sromicki, Juri ;
Vogt, Paul ;
Reser, Diana .
JOURNAL OF THORACIC DISEASE, 2022, 14 (06) :2011-2021
[45]   Long-term outcomes of frozen elephant trunk for type A aortic dissection in patients with Marfan syndrome [J].
Ma, Wei-Guo ;
Zhang, Wei ;
Zhu, Jun-Ming ;
Ziganshin, Bulat A. ;
Zhi, Ai-Hua ;
Zheng, Jun ;
Liu, Yong-Min ;
Elefteriades, John A. ;
Sun, Li-Zhong .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2017, 154 (04) :1175-+
[46]   Long-term age-stratified survival following endovascular and open abdominal aortic aneurysm repair [J].
Varkevisser, Rens R. B. ;
Mota, Mathijs T. Carvalho ;
Swerdlow, Nicholas J. ;
Stone, David H. ;
Scali, Salvatore T. ;
Blankensteijn, Jan D. ;
Verhagen, Hence J. M. ;
Schermerhorn, Marc L. .
JOURNAL OF VASCULAR SURGERY, 2022, 76 (04) :899-+
[47]   Coronary artery disease as an independent predictor of short-term and long-term outcomes in patients with type-B aortic dissection undergoing thoracic endovascular repair [J].
Li, Wei ;
Luo, Songyuan ;
Lin, Wenhui ;
Su, Sheng ;
Xu, Wenmin ;
Hu, Xiaolu ;
Liu, Yuan ;
Huang, Wenhui ;
Luo, Jianfang ;
Zhou, Yingling .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
[48]   Long-term Outcomes of Endovascular Repair of Acute Type B Aortic Dissection: A Systematic Review [J].
Elmisbah, Haider Osman Ibn Idris ;
Sulaiman, Ahmed Hamad ;
Almisbah, Hafiz Osman Ibn Idris ;
Alali, Almaha Ahmed A. ;
Alaqabawi, Reem Mahmoud R. ;
Alanazi, Reem Saud J. ;
Alanazi, Raghad Salman M. .
JOURNAL OF PIONEERING MEDICAL SCIENCES, 2025, 14 (02) :36-41
[49]   The impact of female sex on long-term survival of patients with severe atherosclerosis undergoing endarterectomy [J].
Vrijenhoek, Joyce E. P. ;
Haitjema, Saskia ;
de Borst, Gert Jan ;
de Vries, Jean-Paul P. M. ;
Vaartjes, Ilonca ;
Moll, Frans L. ;
Pasterkamp, Gerard ;
den Ruijter, Hester M. .
ATHEROSCLEROSIS, 2014, 237 (02) :521-527
[50]   Long-Term Survival of Patients With Radiation Heart Disease Undergoing Cardiac Surgery A Cohort Study [J].
Wu, Willis ;
Masri, Ahmad ;
Popovic, Zoran B. ;
Smedira, Nicholas G. ;
Lytle, Bruce W. ;
Marwick, Thomas H. ;
Griffin, Brian P. ;
Desai, Milind Y. .
CIRCULATION, 2013, 127 (14) :1476-1484