Enhancement of transdermal protein delivery by photothermal effect of gold nanorods coated on polysaccharide-based hydrogel

被引：24

作者：

Haine, Aung Thu ^{[1
,2
]}

Koga, Yuki ^{[1
]}

Hashimoto, Yuta ^{[1
]}

Higashi, Taishi ^{[3
]}

Motoyama, Keiichi ^{[3
]}

Arima, Hidetoshi ^{[3
,4
]}

Niidome, Takuro ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Adv Sci & Technol, Dept Appl Chem & Biochem, Chuo Ku, 2-39-1 Kurokami, Kumamoto 8608555, Japan

[2] Yangon Technol Univ, Dept Chem Engn, Insein PO, Gyogone 11011, Yangon, Myanmar

[3] Kumamoto Univ, Grad Sch Pharmaceut Sci, Dept Phys Pharmaceut, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

[4] Kumamoto Univ, Program Leading Grad Sch, HIGO Hlth Life Sci Interdisciplinary & Global Ori, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2017年 / 119卷

基金：

日本学术振兴会;

关键词：

Controlled release; Gold nanorod; Hydrogel; Near-infrared light; Photothermal effect; Transdermal protein delivery; DRUG-DELIVERY; SKIN; IRRADIATION; ABLATION;

D O I：

10.1016/j.ejpb.2017.06.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transdermal protein delivery is a useful and attractive method for protein therapy and dermal vaccination. However, this delivery method is restricted by the low permeability of the stratum corneum. The purpose of this study was to develop a transdermal delivery system for enhancement of protein permeability into the skin. First, we prepared a transparent gel patch made of polysaccharides with gold nanorods on the gel surface and fluorescein isothiocyanate-modified ovalbumin (FITC-OVA) inside. Next, the gel patch was placed on mouse skin to allow contact with the coated gold nanorods, and irradiated by a continuous-wave laser. The laser irradiation heated the gold nanorods and the skin temperature increased to 43 degrees C, resulting in enhanced translocation of FITC-OVA into the skin. These results confirmed the capability of the transdermal protein delivery system to perforate the stratum corneum and thus facilitate the passage of proteins across the skin. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：91 / 95

页数：5

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