The long non-coding RNA ANRIL promotes proliferation and cell cycle progression and inhibits apoptosis and senescence in epithelial ovarian cancer

被引:85
|
作者
Qiu, Jun-jun [1 ,2 ,3 ]
Wang, Yan [4 ,5 ]
Liu, Ying-lei [6 ]
Zhang, Ying [1 ,2 ,3 ]
Ding, Jing-xin [1 ,2 ,3 ]
Hua, Ke-qin [1 ,2 ,3 ]
机构
[1] Fudan Univ, Obstet & Gynecol Hosp, Dept Gynecol, Shanghai 200433, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Obstet & Gynecol, Shanghai 200433, Peoples R China
[3] Fudan Univ, Shanghai Key Lab Female Reprod Endocrine Related, Shanghai 200433, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Canc Inst, Shanghai 200433, Peoples R China
[5] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200433, Peoples R China
[6] Nantong Univ, Affiliated Hosp 2, Dept Gynecol, Nantong, Peoples R China
基金
中国国家自然科学基金;
关键词
ANRIL; proliferation; cell cycle; apoptosis; senescence; GENOME-WIDE ASSOCIATION; POOR-PROGNOSIS; PANCREATIC-CANCER; DOWN-REGULATION; PREDICTS; SUSCEPTIBILITY; EXPRESSION; GAS5; OVEREXPRESSION; IDENTIFICATION;
D O I
10.18632/oncotarget.8744
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Antisense non-coding RNA in the INK4 locus (ANRIL) has been implicated in a variety of cancers. In the present study, we evaluated ANRIL expression in epithelial ovarian cancer (EOC) and defined its clinical implications and biological functions. ANRIL was overexpressed in EOC tissues relative to normal controls. Overexpression correlated with advanced International Federation of Gynecologists and Obstetricians stage and high histological grade. Multivariate analysis indicated that ANRIL is an independent prognostic factor for overall survival in EOC. Gain-and loss-of-function experiments demonstrated that ANRIL promotes EOC cell proliferation both in vitro and in vivo. The proliferative effect was linked to the promotion of cell cycle progression and inhibition of apoptosis and senescence. Down-regulation of P15(INK4B) and up-regulation of Bcl-2 by ANRIL may partially explain ANRIL-induced EOC cell proliferation. This study is the first to establish that ANRIL promotes EOC progression and is a potential prognostic biomarker.
引用
收藏
页码:32478 / 32492
页数:15
相关论文
共 50 条
  • [21] Long non-coding RNA taurine-upregulated gene 1 predicts unfavorable prognosis, promotes cells proliferation, and inhibits cells apoptosis in epithelial ovarian cancer
    Li, Tong-Huai
    Zhang, Jing-Jing
    Liu, Shao-Xiao
    Chen, Yan
    MEDICINE, 2018, 97 (19)
  • [22] E2F1-regulated long non-coding RNA RAD51-AS1 promotes cell cycle progression, inhibits apoptosis and predicts poor prognosis in epithelial ovarian cancer
    Zhang, Xiaodan
    Liu, Guoping
    Qiu, Junjun
    Zhang, Ning
    Ding, Jingxin
    Hua, Keqin
    SCIENTIFIC REPORTS, 2017, 7
  • [23] Interference of long non-coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR-26b-5p
    Zhu, Lin
    Mei, Mei
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 22 (02)
  • [24] Long non-coding RNA 00312 regulated by HOXA5 inhibits tumour proliferation and promotes apoptosis in Non-small cell lung cancer
    Zhu, Qingqing
    Lv, Tangfeng
    Wu, Ying
    Shi, Xuefei
    Liu, Hongbing
    Song, Yong
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2017, 21 (09) : 2184 - 2198
  • [25] Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer
    Sun, Zhenqiang
    Ou, Chunlin
    Ren, Weiguo
    Xie, Xiang
    Li, Xiayu
    Li, Guiyuan
    ONCOTARGET, 2016, 7 (30) : 47536 - 47555
  • [26] Long Non-coding RNA LOC285194 Promotes Epithelial Ovarian Cancer Progression via the Apoptosis Signaling Pathway
    Yim, Ga Won
    Lee, Dae Woo
    Kim, Jae In
    Kim, Young Tae
    IN VIVO, 2022, 36 (01): : 121 - 131
  • [27] Upregulation of long non-coding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression
    Yang, Liu
    Qiu, Mantang
    Xu, Youtao
    Wang, Jie
    Zheng, Yanyan
    Li, Ming
    Xu, Lin
    Yin, Rong
    ONCOLOGY REPORTS, 2016, 35 (01) : 318 - 324
  • [28] Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2
    Huang, Ming-de
    Chen, Wen-ming
    Qi, Fu-zhen
    Xia, Rui
    Sun, Ming
    Xu, Tong-peng
    Yin, Li
    Zhang, Er-bao
    De, Wei
    Shu, Yong-qian
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2015, 8
  • [29] Long non-coding RNA ANRIL overexpression predicts poor prognosis and promotes metastasis and proliferation in perihilar cholangiocarcinoma
    Li, Zhendong
    Wu, Xianlin
    Li, Jiexing
    Li, Xuguang
    Liu, Dasheng
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 11 (07): : 7029 - 7037
  • [30] Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis
    Zhao, Zhijun
    Wang, Bin
    Hao, Junhai
    Man, Weitao
    Chang, Yongkai
    Ma, Shunchang
    Hu, Yeshuai
    Liu, Fusheng
    Yang, Jun
    ONCOLOGY LETTERS, 2018, 15 (03) : 4026 - 4032