Wilsoniamines A and B: novel alkaloids from the temperate Australian bryozoan, Amathia wilsoni

被引：24

作者：

Carroll, Anthony R. ^{[1
,2
]}

Duffy, Sandra ^{[2
]}

Sykes, Melissa ^{[2
]}

Avery, Vicky M. ^{[2
]}

机构：

[1] Griffith Univ, Environm Futures Ctr, Gold Coast, Qld 4222, Australia

[2] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 02期

关键词：

AMATHAMIDE ALKALOIDS; STRECKER REACTION;

D O I：

10.1039/c0ob00538j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel alkaloids, wilsoniamines A and B, both possessing a hexahydropyrrolo[1,2-c]imidazol-1-one ring system that has not previously been found in nature, together with a new alkaloid, amathamide H and a known alkaloid, amathamide C were isolated from the temperate Australian bryozoan, Amathia wilsoni. MS and NMR analysis established the structure of the new compounds and indicated that the structure of amathamide C and several related compounds be revised. Amathamides C and H showed moderate anti-malarial and anti-trypanosomal activity.

引用

页码：604 / 609

页数：6

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