The Role of Kisspeptin Signaling in Reproduction

被引:122
作者
de Tassigny, Xavier d'Anglemont [1 ]
Colledge, William Henry [1 ]
机构
[1] Univ Cambridge, Reprod Physiol Grp, Dept Physiol Dev & Neurosci, Cambridge, England
关键词
PROTEIN-COUPLED-RECEPTOR; HYPOTHALAMIC KISS-1 SYSTEM; MONKEY MACACA-MULATTA; ANTEROVENTRAL PERIVENTRICULAR NUCLEUS; RIBONUCLEIC-ACID EXPRESSION; LUTEINIZING-HORMONE RELEASE; ESTROGEN POSITIVE FEEDBACK; MESSENGER-RNA EXPRESSION; GENE-EXPRESSION; ARCUATE NUCLEUS;
D O I
10.1152/physiol.00009.2010
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.
引用
收藏
页码:207 / 217
页数:11
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