The Role of Kisspeptin Signaling in Reproduction

被引：121

作者：

de Tassigny, Xavier d'Anglemont ^{[1
]}

Colledge, William Henry ^{[1
]}

机构：

[1] Univ Cambridge, Reprod Physiol Grp, Dept Physiol Dev & Neurosci, Cambridge, England

来源：

PHYSIOLOGY | 2010年 / 25卷 / 04期

关键词：

PROTEIN-COUPLED-RECEPTOR; HYPOTHALAMIC KISS-1 SYSTEM; MONKEY MACACA-MULATTA; ANTEROVENTRAL PERIVENTRICULAR NUCLEUS; RIBONUCLEIC-ACID EXPRESSION; LUTEINIZING-HORMONE RELEASE; ESTROGEN POSITIVE FEEDBACK; MESSENGER-RNA EXPRESSION; GENE-EXPRESSION; ARCUATE NUCLEUS;

D O I：

10.1152/physiol.00009.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Kisspeptins are a group of peptides that stimulate GnRH release and are required for puberty and maintenance of normal reproductive function. This review focuses on our understanding of the way in which kisspeptin signaling regulates mammalian fertility and how they act as central integrators of different hormonal and physiological signals.

引用

页码：207 / 217

页数：11

共 123 条

[1] Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats [J].

Adachi, Sachika ;

Yamada, Shunji ;

Takatsu, Yoshihiro ;

Matsui, Hisanori ;

Kinoshita, Mika ;

Takase, Kenji ;

Sugiura, Hitomi ;

Ohtaki, Tetsuya ;

Matsumoto, Hirokazu ;

Uenoyama, Yoshihisa ;

Tsukamura, Hiroko ;

Inoue, Kinji ;

Maeda, Kei-Ichiro .

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2007, 53 (02) :367-378

[2] Melanocortins May Stimulate Reproduction by Activating Orexin Neurons in the Dorsomedial Hypothalamus and Kisspeptin Neurons in the Preoptic Area of the Ewe [J].

Backholer, Kathryn ;

Smith, Jeremy ;

Clarke, Iain J. .

ENDOCRINOLOGY, 2009, 150 (12) :5488-5497

[3] Coexpression of dynorphin and neurokinin B immunoreactlivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus [J].

Burke, Michelle C. ;

Letts, Penny A. ;

Krajewski, Sally J. ;

Rance, Naomi E. .

JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 498 (05) :712-726

[4] Kisspeptin synchronizes Preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes [J].

Caraty, A. ;

Smith, J. T. ;

Lomet, D. ;

Ben Saied, S. ;

Morrissey, A. ;

Cognie, J. ;

Doughton, B. ;

Baril, G. ;

Briant, C. ;

Clarke, I. J. .

ENDOCRINOLOGY, 2007, 148 (11) :5258-5267

[5] Alterations in Hypothalamic KiSS-1 System in Experimental Diabetes: Early Changes and Functional Consequences [J].

Castellano, J. M. ;

Navarro, V. M. ;

Roa, J. ;

Pineda, R. ;

Sanchez-Garrido, M. A. ;

Garcia-Galiano, D. ;

Vigo, E. ;

Dieguez, C. ;

Aguilar, E. ;

Pinilla, L. ;

Tena-Sempere, M. .

ENDOCRINOLOGY, 2009, 150 (02) :784-794

[6] Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition [J].

Castellano, JM ;

Navarro, VM ;

Fernández-Fernández, R ;

Nogueiras, R ;

Tovar, S ;

Roa, J ;

Vazquez, MJ ;

Vigo, E ;

Casanueva, FF ;

Aguilar, E ;

Pinilla, L ;

Dieguez, C ;

Tena-Sempere, M .

ENDOCRINOLOGY, 2005, 146 (09) :3917-3925

[7] Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats [J].

Castellano, Juan M. ;

Navarro, Victor M. ;

Fernandez-Fernandez, Rafael ;

Roa, Juan ;

Vigo, Eva ;

Pineda, Rafael ;

Dieguez, Carlos ;

Aguilar, Enrique ;

Pinilla, Leonor ;

Tena-Sempere, Manuel .

DIABETES, 2006, 55 (09) :2602-2610

[8] Effects of Photoperiod on Kisspeptin Neuronal Populations of the Ewe Diencephalon in Connection with Reproductive Function [J].

Chalivoix, S. ;

Bagnolini, A. ;

Caraty, A. ;

Cognie, J. ;

Malpaux, B. ;

Dufourny, L. .

JOURNAL OF NEUROENDOCRINOLOGY, 2010, 22 (02) :110-118

[9] Kisspeptin/Gpr54-Independent Gonadotrophin-Releasing Hormone Activity in Kiss1 and Gpr54 Mutant Mice [J].

Chan, Y. M. ;

Broder-Fingert, S. ;

Wong, K. M. ;

Seminara, S. B. .

JOURNAL OF NEUROENDOCRINOLOGY, 2009, 21 (12) :1015-1023

[10]

CHENG G, ENDOCRINOLOGY, V151, P301

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