Biological analysis and imaging applications of CdSe/CdSxSe1-x/CdS core-shell magic-sized quantum dot

被引：20

作者：

Almeida Silva, Anielle Christine ^{[1
]}

Peres Freschi, Ana Paula ^{[1
,2
]}

Rodrigues, Claudia Mendonca ^{[2
]}

Matias, Bruna Franca ^{[2
]}

Maia, Larissa Prado ^{[2
]}

Goulart, Luiz Ricardo ^{[2
,3
]}

Dantas, Noelio Oliveira ^{[1
]}

机构：

[1] Univ Fed Uberlandia, Inst Phys, LNMIS, Av Engenheiro Dinz 1178,CP 593, BR-38400 Uberlandia, MG, Brazil

[2] Univ Fed Uberlandia, Inst Genet & Biochem, Lab Nanobiotecnol, Av Engenheiro Dinz 1178,CP 593, BR-38400 Uberlandia, MG, Brazil

[3] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2016年 / 12卷 / 05期

关键词：

CdSe/CdSxSe1-x/CdS CS-MSQDs; Biocompatible; Bioconjugation; Biomedical imaging; Breast cancer; GROWTH-FACTOR-BETA; CDSE; CYTOTOXICITY; CDTE; NANOPARTICLES; LUMINESCENCE; ATTACHMENT; TOXICITY; CELLS;

D O I：

10.1016/j.nano.2016.01.001

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Although colloidal magic-sized quantum dots present great promise for biological applications due to their high stability and strong luminescence, nanotoxicological analyses are scarcely reported and biomedical applications have not been demonstrated. This is the first report on biological effects of CdSe/CdSxSe1-x/CdS core-shell magic-sized quantum dot (CS-MSQD) with specific application in breast cancer cell detection. The 2-nm CS-MSQD presents a broad bandwidth emission from 450 to 750 nm, low toxicity, non-immunogenicity and biocompatibility. The CS-MSQD was conjugated to a breast cancer-specific Fab antibody, and passively diffused into cells for in vitro detection of a breast cancer cell line, demonstrating to be an unprecedented tool for biomedical applications. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：1421 / 1430

页数：10

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