Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat

被引：28

作者：

Kawai, Hiromi ^{[1
]}

Deguchi, Shoko ^{[1
]}

Deguchi, Kentaro ^{[1
]}

Yamashita, Toru ^{[1
]}

Ohta, Yasuyuki ^{[1
]}

Shang, Jingwei ^{[1
]}

Tian, Fengfeng ^{[1
]}

Zhang, Xuemei ^{[1
]}

Liu, Ning ^{[1
]}

Liu, Wentao ^{[1
]}

Ikeda, Yoshio ^{[1
]}

Matsuura, Tohru ^{[1
]}

Abe, Koji ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan

来源：

BRAIN RESEARCH | 2011年 / 1368卷

关键词：

Cerebral infarction; Amlodipine; Atorvastatin; Oxidative stress; Inflammatory; Zucker rat; SPONTANEOUSLY HYPERTENSIVE-RATS; CALCIUM-CHANNEL BLOCKERS; FOCAL CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; UP-REGULATION; THERAPY; OBESITY; INJURY; BRAIN; NEUROPROTECTION;

D O I：

10.1016/j.brainres.2010.10.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stroke is a major neurologic disorder and a leading cause of death in the world. We compared neuroprotective effects of single or combination therapy of amlodipine (AM) and atorvastatin (AT) in such a metabolic syndrome model Zucker rat after 90 min of transient middle cerebral artery occlusion (tMCAO). The animals were pretreated with vehicle, AM, AT, or the combination of AM plus AT for 28 days, and at 24 h of tMCAO, infarct volume and immunohistochemical analyses were performed. The combination of AM plus AT treatment decreased the infarct volume stronger than each single treatment with AM or AT. The numbers of positive cells of oxidative stress markers such as 8-hydroxy-2'-deoxyguanosin (8-OHdG), 4-hydroxy-2-nonenal (4-HNE), and advanced end glycation products (AGE) and inflammation markers such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) decreased dramatically in the combination-treated group compared with single AM or AT-treated group. The present study showed that single AM or AT treatment showed neuroprotective effects both with antioxidative and anti-inflammatory mechanisms, but combination therapy of AM plus AT presented a further synergistic benefit in acute ischemic neural damages. (C) 2010 Elsevier BM. All rights reserved.

引用

页码：317 / 323

页数：7

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