Zearalenone occurrence and human exposure

Among the mycotoxins zearalenone (ZEA) is of interest because of the oestrogenic effects that it, and certain of its metabolites possess The fungi that produce ZEA are found worldwide, particularly in cereal grains and derived products This has prompted many surveys to detect these compounds in commodities and foods As a result, the widespread occurrence of ZEA in foods is well documented Previous summaries including extensive reports by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), the European Commission's Scientific Cooperation on Questions Relating to Food (SCOOP), and others, have provided significant information on the occurrence of ZEA in commodities and foods Publication of occurrence data has continued at a rapid pace, and certain of that data, as well as highlights from previous intake and exposure assessments, are summarised herein Comparing estimates of intake (exposure) with previous estimates of tolerable daily intakes, suggests that, for many of the countries where exposure assessments have been done, the populations are exposed to levels that would be considered safe The situation may be different in populations that consume large quantities of foods that are susceptible to contamination, or in instances where contamination is atypically high For much of the world estimates of exposure have not been reported, meaning that for much of the world, the true extent of the relevance of ZEA to human health remains uncharacterised