Photoinduced Trifluoromethylation with CF3Br as a Trifluoromethyl Source: Synthesis of α-CF3-Substituted Ketones

被引:19
作者
Ma, Ransong [1 ]
Deng, Zhoubin [1 ]
Wang, Ke-Hu [1 ]
Wang, Junjiao [1 ]
Huang, Danfeng [1 ]
Su, Yingpeng [1 ]
Hu, Yulai [1 ,3 ]
Lv, Xiaobo [2 ]
机构
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Peoples R China
[2] Shanghai Sinofluoro Chem Co Ltd, Shanghai 201321, Peoples R China
[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源
ACS OMEGA | 2022年 / 7卷 / 16期
基金
中国国家自然科学基金;
关键词
SILYL ENOL ETHERS; PET-OXIDATIVE CYCLIZATION; ALKENES; HYDROTRIFLUOROMETHYLATION; BROMOTRIFLUOROMETHANE; REAGENTS; ALKYNES; ARENES;
D O I
10.1021/acsomega.2c01241
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An efficient and novel photoinduced trifluoromethylation employing CF3Br as a trifluoromethyl source is described. With commercially accessible fac-Ir(III)(ppy)3 as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF3Br occurs successfully. This method provides various alpha-CF3-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.
引用
收藏
页码:14357 / 14362
页数:6
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