Optimized catalysts for the asymmetric addition of trimethylsilyl cyanide to aldehydes and ketones

被引：166
作者：
Belokon, YN
Green, B
Ikonnikov, NS
North, M
Parsons, T
Tararov, VI
机构：
[1] Kings Coll London, Dept Chem, London WC2R 2LS, England
[2] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 117813, Russia
[3] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales
来源：
TETRAHEDRON | 2001年 / 57卷 / 04期
基金：
英国工程与自然科学研究理事会; 俄罗斯基础研究基金会;
关键词：
cyanohydrins; asymmetric synthesis; catalysis; transition metals;
D O I：
10.1016/S0040-4020(00)01053-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A bimetallic titanium(IV)salen complex has been developed as an exceptionally active catalyst for the asymmetric addition of trimethylsilyl cyanide to ketones. For the corresponding addition to aldehydes, a vanadium(IV)salen complex was found to give higher levels of asymmetric induction. In both cases, additional evidence in support of the proposed catalytic cycle is presented. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：771 / 779
页数：9
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