Antibody-free detection of protein phosphorylation using intrinsic peroxidase-like activity of platinum/carbon dot hybrid nanoparticles

被引：21
作者：
Wang, Yuzhen [1 ,2 ,3 ]
Qi, Wenjin [4 ]
Song, Yujun [1 ]
机构：
[1] Nanjing Univ, Coll Engn & Appl Sci, Dept Biomed Engn, Nanjing 210093, Jiangsu, Peoples R China
[2] Houston Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA
[3] Cornell Univ, Weill Med Coll, New York, NY 10065 USA
[4] Kunming Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Kunming 660032, Yunnan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 51期
基金：
中国国家自然科学基金;
关键词：
MASS-SPECTROMETRY; KINASE; RECEPTOR; PHOSPHOPROTEOME; INHIBITION; RADIATION; CANCER; CELLS;
D O I：
10.1039/c6cc02771g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Platinum and carbon dot hybrid nanomaterials are prepared for visualized detection of phosphoproteins without the need for antibodies or enzymes. This new strategy can be used for colorimetric detection of phosphoproteins induced by protein kinase as well as protein phosphorylation sites on cell membranes.
引用
收藏
页码：7994 / 7997
页数：4
相关论文
共 28 条
  • [1] The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1 beta (Rsk-2) and p70 S6 kinase
    Alessi, DR
    [J]. FEBS LETTERS, 1997, 402 (2-3) : 121 - 123
  • [2] Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer
    Bianco, Cataldo
    Giovannetti, Elisa
    Ciardiello, Fortunato
    Mey, Valentina
    Nannizzi, Sara
    Tortora, Giampaolo
    Troiani, Teresa
    Pasqualetti, Francesco
    Eckhardt, Gail
    de Liguoro, Mario
    Ricciardi, Simona
    Del Tacca, Mario
    Raben, David
    Cionini, Luca
    Danesi, Romano
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (23) : 7099 - 7107
  • [3] Oncogenic kinase signalling
    Blume-Jensen, P
    Hunter, T
    [J]. NATURE, 2001, 411 (6835) : 355 - 365
  • [4] Fine Tuning of Protein Kinase C (PKC) Isoforms in Cancer: Shortening the Distance from the Laboratory to the Bedside
    Bosco, R.
    Melloni, E.
    Celeghini, C.
    Rimondi, E.
    Vaccarezza, M.
    Zauli, G.
    [J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2011, 11 (03) : 185 - 199
  • [5] Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
    Carter, TA
    Wodicka, LM
    Shah, NP
    Velasco, AM
    Fabian, MA
    Treiber, DK
    Milanov, ZV
    Atteridge, CE
    Biggs, WH
    Edeen, PT
    Floyd, M
    Ford, JM
    Grotzfeld, RM
    Herrgard, S
    Insko, DE
    Mehta, SA
    Patel, HK
    Pao, W
    Sawyers, CL
    Varmus, H
    Zarrinkar, PP
    Lockhart, DJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (31) : 11011 - 11016
  • [6] BIOSYNTHETIC LABELING WITH P-32 - RADIATION-DAMAGE TO MAMMALIAN-CELLS
    COOPER, PC
    BURGESS, AW
    [J]. ANALYTICAL BIOCHEMISTRY, 1985, 144 (02) : 329 - 335
  • [7] Carbon dot reduced palladium nanoparticles as active catalysts for carbon-carbon bond formation
    Dey, Deepa
    Bhattacharya, Tamalika
    Majumdar, Biju
    Mandani, Sonam
    Sharma, Bhagwati
    Sarma, Tridib K.
    [J]. DALTON TRANSACTIONS, 2013, 42 (38) : 13821 - 13825
  • [8] Specific capture of phosphopeptides by Zr4+-modified monolithic capillary column
    Dong, Jing
    Zhou, Houjiang
    Wu, Renan
    Ye, Mingliang
    Zou, Hanfa
    [J]. JOURNAL OF SEPARATION SCIENCE, 2007, 30 (17) : 2917 - 2923
  • [9] Fan KL, 2012, NAT NANOTECHNOL, V7, P459, DOI [10.1038/NNANO.2012.90, 10.1038/nnano.2012.90]
  • [10] Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
    Gao, Lizeng
    Zhuang, Jie
    Nie, Leng
    Zhang, Jinbin
    Zhang, Yu
    Gu, Ning
    Wang, Taihong
    Feng, Jing
    Yang, Dongling
    Perrett, Sarah
    Yan, Xiyun
    [J]. NATURE NANOTECHNOLOGY, 2007, 2 (09) : 577 - 583
123