Synthesis of tetrasubstituted Zn(II)-phthalocyanines carrying four carboranyl-units as potential BNCT and PDT agents

被引：40
作者：
Giuntini, F
Raoul, Y
Dei, D
Municchi, M
Chiti, G
Fabris, C
Colautti, P
Jori, G
Roncucci, G
机构：
[1] Molteni Farmaceut, I-50018 Scandicci, FI, Italy
[2] Univ Padua, Dipartimento Biol, I-35121 Padua, Italy
[3] Ist Nazl Fis Nucl, Lab Nazl Legnaro, I-35020 Legnaro, PD, Italy
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 17期
关键词：
zinc(II)phthalocyaninm; carboranes; PDT; BNCT;
D O I：
10.1016/j.tetlet.2005.03.030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of two tetrasubstituted zinc(II)phthalocyanines carrying four carbon-carbon linked nu-carboranyl-units (40 boron atoms, 27.5% boron by weight) is presented. In an in vitro model test the new compounds showed a good photosensitizing efficiency, that encourages further studies for their evaluation as possible BNCT-PDT sensitizers. (c) 2005 Elsevier Ltd. All rights reserved.
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页码：2979 / 2982
页数：4
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